It is a hypnotic drug with a chemical structure similar to that of benzodiazepines, barbiturates, and other drugs with hypnotic properties. However, zolpidem is a gamma-aminobutyric acid-benzodiazepine complex.
It has no anticonvulsant and muscle relaxant properties. Its absorption from the gastrointestinal tract is rapid and food absorbs its delay. The rate of binding of this drug to plasma proteins is 92.5%. In the liver, it is converted to inactive metabolites. Most excretion occurs in the urine. The elimination half-life of the drug is about two and a half hours.
Short-term treatment of insomnia.
Significant drug interactions
CNS suppressants may increase the effect of zolpidem suppressant on the CNS.
Alcohol consumption may further suppress the central nervous system. Encourage the patient to stop drinking alcohol.
Contraindications and precautions
Caution should be exercised in patients with disorders that affect metabolism or hemodynamic responses, and in patients with decreased respiratory effort, depression, or a history of alcohol or drug abuse.
Most common: Allergic reactions
Most important: headache
Abnormal dreams, forgetfulness, drowsiness during the day, depression, dizziness, lethargy, lightheadedness, sleep disturbance, chest pain, palpitations, pharyngitis, sinusitis, abdominal pain, constipation, diarrhea, dry mouth, dyspepsia Nausea, vomiting, joint pain, low back pain, myalgia, skin rash, cold-like symptoms
Consumption in pregnancy and lactation
Appears in breast milk, so avoid prescribing it to breastfeeding women.
Poisoning and treatment
The effects of drug overdose can range from drowsiness to mild coma. It is also possible to weaken the cardiovascular and respiratory status. Perform routine symptomatic and supportive measures by rinsing the stomach immediately (if necessary). Use intravenous fluids as needed. Prescription
Flumazenil may be helpful. Monitoring and treating the patient for hypotension and CNS impairment is essential. Even if you have symptoms of irritability, stop taking sedatives after zolpidem poisoning.
Limit treatment with zolpidem to 2 to 4 days. If the patient needs to take medication for more than 2 weeks, re-evaluation of the patient is necessary.
Sleep disturbance may be due to physical or mental problems. Prescribe medication after evaluating the patient.
The CNS depressant effects on the CNS are similar to those of other sedatives – hypnotics because the onset of action is rapid. Medication should be taken immediately before going to sleep.
Due to the increased side effects, the dose of zolpidem needs to be adjusted while taking CNS depressant drugs at the same time.
Avoid cumulative or cumulative poisoning with this drug in those hospitalized patients with a history of depression attempting suicide or proven drug abuse. Careful monitoring of patients with a history of drug addiction or abuse is essential. Because there is a risk of addiction or drug dependence.
The efficacy and safety of this drug have not been established in sick children.
Elderly patients develop cognitive or motor impairment after repeated use or due to unusual sensitivity to sedatives.
Advise the patient: Do not take the drug with or immediately after a meal.
If you take the drug for more than a few weeks, there is a possibility of tolerance and the need to take higher doses for the effects of the drug to appear.
Concomitant use of alcohol or other hypnotic compounds during treatment with zolpidem can cause serious side effects.
Consult your doctor to find out how much and how to take the medicine.
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