Zepadic Indications
It is used to control anxiety disorders or to relieve short-term anxiety symptoms and to treat withdrawal symptoms. Injectable diazepam is used as a prodrug to relieve anxiety and stress before surgery. It is also used as an adjunct to intravenous injection to restore normal heart rhythm (CARDIOVERSION) to reduce anxiety. Injectable diazepam is used as an adjunct in the treatment of epileptic seizures and orally in seizure disorders (7-14 days). It is also used as an adjunct in the relief of musculoskeletal spasms.
Zepadic Mechanism of action
It is well absorbed orally. It is metabolized in the liver. The binding of diazepam to plasma proteins is very high. Its half-life is 20-70 hours and the time required for the peak plasma concentration orally is 0.5-2 hours. This drug is excreted through the kidneys. The onset of action of the drug after consuming a single dose orally depends on its rapid absorption and after consuming large amounts on the rate and rate of drug accumulation and in turn on its elimination half-life and clearance.
Zepadic Warnings
- It should be used with extreme caution in severe cases: Severe alcohol intoxication with impaired vital signs, shock coma, acute angle-closure or susceptibility to myasthenia gravis, chronic and severe respiratory obstruction.
- Benzodiazepines may cause respiratory distress in the elderly, adolescents, or the critically ill. In these people, a small reduction in medication may be necessary.
- Prolonged use or large amounts of benzodiazepines may cause psychological and physical dependence.
- The patient should be monitored for 2-3 hours after injecting the products.
- Intravenous injection of benzodiazepines may cause apnea, hypotension, bradycardia, or respiratory arrest.
- Respiratory resuscitation should be available when injecting benzodiazepines.
- Due to the risk of thrombophlebitis, intravenous injection should be performed at a maximum rate of 5 mg / min.
Zepadic Side Effects
Forgetfulness, anxiety disorder, mental depression, tachycardia, and palpitations, ataxia, dizziness and drowsiness, drowsiness (including daytime drowsiness) Speech problems, insomnia, irritability and anger have been reported with this medication.
Zepadic Drug interactions
CNS depressant effects and the risk of apnea may be exacerbated by concomitant use of alcohol-containing products and other CNS depressant drugs. Concomitant use of benzodiazepines with itraconazole and ketoconazole may inhibit the metabolism of these drugs and thus increase the plasma concentration of this drug.
Recommended tips Zepadic
- This medicine should not be taken more than the prescribed amount.
- If after a few weeks, the effectiveness of the drug decreases, you should see a doctor and refrain from increasing the dose.
- As an anticonvulsant, the course of treatment should be complete. Care should be taken not to forget any of the doses.
- In order to reduce the risk of side effects of drug discontinuation, the drug should be discontinued gradually.
- If injected intramuscularly, the drug should be injected deep into the deltoid muscle.
- Intravenous injection should not be given into small veins in the back of the hand or wrist to reduce venous thrombosis, phlebitis, local irritation, and swelling.
- Continuous intravenous infusion of this drug is not recommended.
Zepadic Dosage
Zepadic Oral
Adults: as an anxiolytic, 2-10 mg, 2-4 times a day, as a sedative – hypnotic (in the treatment of withdrawal symptoms) 10 mg 3 or 4 times a day as needed. As an anticonvulsant, 2-10 mg 2-4 times a day and as an adjunct in the relief of skeletal muscle spasm is taken 2-10 mg 3 or 4 times a day.
Children: In children older than 6 months, 1.5-2.2 mg / kg or 0.04-0.0-0 mg / kg, three or four times a day. Then the amount of consumption gradually increases according to the needs and tolerance of the patient.
Zepadic Injection
Adults: Prior to surgery as an anxiolytic, the amount of medication is determined for each patient individually. (As a guide, 10 mg 1-2 hours before surgery is injected intravenously or intramuscularly.) In the treatment of anxiety disorders, 2-10 mg intravenously or intramuscularly. ) 5-10 mg as an anticonvulsant (repeated every 10-15 minutes if needed) Normal heart, 5-15 mg is injected 10-20 minutes before intravenous surgery. As a muscle relaxant, 5-10 mg is first injected intravenously or intramuscularly, which is repeated at intervals of 3 or 4 hours if necessary.
Zepadic for Children
As an anxiolytic, the dose for children older than 30 days is determined separately. As an anticonvulsant, in children older than 30 days and less than 5 years (up to 5 mg) is slowly injected intravenously 0.5-0.2 mg. If necessary, this amount is repeated every 2-5 minutes.
In children over 5 years of age, one milligram is slowly injected intravenously, repeated every 2-5 minutes if needed. (Maximum 10 mg) As a muscle relaxant, 1-2 mg is slowly injected intravenously in children older than one month and less than 5 years. Repeat every 3-4 hours if needed. In children over 5 years of age, 5-10 mg is slowly injected intravenously and repeated as needed every 3-4 hours.
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