Pyridoxine is used to prevent and treat a deficiency of this vitamin. Large amounts of pyridoxine are used to treat some metabolic disorders, such as urinary oxalate. It may also be used in sideroblastic anemia.
Mechanism of action Vibsix
Pyridoxine is converted to pyridoxal phosphate in red blood cells, which acts as a coenzyme in various metabolic functions affecting the consumption of protein, carbohydrates and fats. Pyridoxine is also involved in the conversion of tryptophan to niacin or serotonin, the breakdown of glycogen, the conversion of oxalate to glycine, and the synthesis of gamma aminobutyric acid in the central nervous system.
B vitamins are easily absorbed from the gastrointestinal tract. Pyridoxine is mainly absorbed from the jejunum. Pyridoxylate phosphate is fully bound to plasma proteins, whereas pyridoxine is not bound to plasma proteins. Pyridoxine is mainly stored in the liver. The metabolism of this vitamin is hepatic and its half-life is 15-20. It is almost completely excreted by the kidneys as a metabolite.
prohibited usage Vibsix
Vitamin B6 dependence syndrome has been reported with more than 200 mg / day for more than 30 days.
Drug interactions Vibsix
Concomitant use of vitamin B6 with levodopa is not recommended, as the anti-Parkinson effect of levodopa is reversed, even with oral administration of 5 mg of vitamin B6.
Recommended tips Vibsix
- Because B-vitamin deficiencies alone are not common, a combination of these vitamins is usually prescribed.
- If you miss a dose, it is not necessary to take the missed dose because it takes a long time to drain the vitamin. The course of treatment must be completed according to plan.
As a vitamin supplement, to prevent vitamin deficiency, the recommended daily intake is as follows:
Infants and children from birth to age 3 years 0.1-3 mg, age 4-6 years 1.1 mg, age 7-10 years 1.4 mg boys and adult men 1.7-2 mg, Adult girls and women 1.6 / 1-4 mg, pregnant women 2.2 mg, during lactation 2.1 mg. In the treatment of vitamin deficiency, the dose is determined based on the severity of the deficiency.
To prevent and treat vitamin B6 deficiency as part of total intravenous nutrition, the dose is determined according to the patient’s needs. In the treatment of pyridoxine dependence syndrome in adults, 30-600 mg / day is given first, and in infants, first 100-100 mg is injected intramuscularly or intravenously. In the treatment of drug deficiency due to medication in adults, 50-200 mg / day is used for 3 weeks, which can be continued with 25-100 mg / day if needed.
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