This vitamin is used in the treatment of pernicious anemia caused by the lack or inhibition of internal factors. This drug is used to prevent and deficiency of vitamin B12 and to prevent its deficiency after removing the whole stomach and a large part of the eltum.
Mechanism of action Vibalmin
Vitamin B12 as a coenzyme is involved in various metabolic functions such as carbohydrate and fat metabolism and protein production, and mainly due to its effect on the metabolism of methylene, folic acid and manolic, essential for cell growth and proliferation, hematopoiesis and nucleoprotein and myelin production.
The binding of this vitamin to a special protein called transcobalamin is high. 90% of the drug is stored in the liver. Its metabolism is hepatic and its half-life is approximately 6 days (400 days in the liver). The time required to reach the peak plasma concentration by intramuscular injection is 60 minutes. Vitamin B12 is excreted in the bile. Excess daily amounts are excreted unchanged in the urine.
prohibited usage Vibalmin
This medicine should not be used in Leber’s disease.
Diagnosis of vitamin B12 deficiency should be confirmed by laboratory tests before starting treatment. Invitamin administration may mask folic acid deficiency.
Vitamin B12 should not be injected intravenously, although small amounts are present in solutions prepared for those who are only injecting.
side effects Vibalmin
In case of pernicious anemia or after removal of the whole stomach and removal of a large part of the ileum, the drug should be continued for the rest of life. Since deficiency of B vitamins alone is not common, a combination of these vitamins is usually prescribed.
Adults: In the prevention of vitamin deficiency, as part of total intravenous nutrition, the dose is determined based on the needs of each patient. In the treatment of vitamin deficiency, 0.1 mg / day is injected intramuscularly every 6-7 days. In case of clinical improvement and reticulocyte response, 0.1 mg is injected every other day. Then 0.1 mg every 3-4 days for 2-3 weeks is injected intramuscularly. The maintenance dose is 0.1-2.1 mg once a month, which is injected intramuscularly.
Children: In the prevention of vitamin deficiency as part of intravenous nutrition, the dose is determined based on the needs of each patient. In the treatment of vitamin deficiency, 30-50 mcg / day is injected intramuscularly for two weeks or more. As a preservative, 0.1 mg is given intramuscularly once a month for two weeks (if needed).
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