What is Trifluoperazine?
Trifloprazine is one of the drugs that affects the nervous system and is prescribed in the treatment of some neurological disorders such as schizophrenia, behavioral disorders, etc.
It is sometimes prescribed as a sedative in cases of anxiety, restlessness or suspicion of others, and attacks of acute depression. It belongs to a group of drugs called phenothiazines.
Also, one of the side effects of this drug is its antiemetic effect, which is sometimes used as a therapeutic effect.
Before taking Trifluoperazine
Be sure to tell your doctor if you have a history of allergies to this drug or similar drugs such as chlorpromazine, thioridazine, perphenazine, flofenazine, or any other medication.
If you have a history of severe depression, blood disease, bone marrow suppression-related illness, vascular disease, irregular heartbeat, severe hypotension, angina pectoris, high blood pressure (glaucoma), seizures, type 2 diabetes, high cholesterol Be sure to tell your doctor.
Tell your doctor if you are pregnant, breastfeeding or planning to become pregnant.
This drug is not suitable for people with liver disorders, so before starting to take the clinical tests prescribed by your doctor to ensure that your liver and blood condition are suitable for starting this drug.
Tell your doctor if you have a family history of blood clotting or blood clotting disorders.
Be sure to tell your doctor if you use alcohol or tobacco.
Provide a complete list of all medications (even over-the-counter medications), supplements, and herbal products to your doctor or pharmacist to avoid serious drug interactions that may occur with concomitant use of this medication with other medications. To be prevented.
Concomitant use of this drug with nitrate-containing drugs (such as nitroglycerin) increases the risk of severe hypotension.
Concomitant use of this drug with other drugs that weaken the nerves, intensifies the weakening effect of these drugs, so before starting to take any sedative, be sure to consult your doctor.
The correct way to take Trifluoperazine
Take the medicine exactly as prescribed by the doctor and in the specified intervals and continue taking the medicine until the doctor recommends it.
Taking this drug with syrups and antacids can reduce the absorption of this drug, and if you need to take them at the same time, at least two hours between taking this drug and antacids is necessary.
If you are unable to swallow the pill, you can crush it and dissolve it in water or other decaffeinated liquids.
Injectable form of this drug should be used only in the medical center or under the supervision of a doctor.
Abrupt discontinuation of this drug can have serious and annoying side effects, so discontinuation of the drug should only be done under the supervision of a physician and gradually.
– If you forget to take this medicine once, take it as soon as you are reminded, but if this medicine has been prescribed to you more than twice a day, if you forget to take this medicine once, up to one hour after the prescribed time. You can take it, otherwise, do not take the missed dose and take the next dose according to the previous plan and avoid doubling the amount of medicine in one separate dose.
Therapeutic response to this drug is usually observed 2 to 3 weeks after starting treatment. Therefore, be patient until the medicine works and continue taking it regularly under the supervision of your doctor.
Recommendations for the use of Trifluoperazine
You may feel a sudden warmth or cold while taking this medicine and your body may sweat a lot. Therefore, be more careful when the temperature is too high or too low (hot or cold) and do not expose yourself to very hot weather as much as possible.
Do not drink alcohol while taking this medicine. Concomitant use of this drug with alcoholic products can greatly increase the hypnotic and confusing effect of this drug.
If you inadvertently take more medicine than prescribed, go to a health center or doctor right away and take the medicine package with you. Symptoms of intoxication include difficulty moving, low blood pressure, confusion, and imbalance.
Important side effects of Trifluoperazine
Postural hypotension and dizziness are common when taking this drug.
Avoid sudden changes to reduce the chance of it happening. (For example, from a supine position, first change to a sitting position and then slowly get up after a few seconds.)
Symptoms such as sore throat, fever, unusual bleeding or bruising on the body, red skin spots, weakness, tremors, dark urine and pain and frequent bowel movements, jaundice of the skin or eyes, abnormal Be sure to see your doctor if you have vision or clear stools.
Be sure to see your doctor if you have cramps in the neck muscles or protruding tongue, abnormal movement of the lips, eyes, face, etc.
Dry mouth caused by this drug can be eliminated by consuming chewing gum and sugar-free candies.
If you develop constipation or diarrhea during treatment with this drug, drink plenty of fluids and see your doctor if it persists.
During treatment with this drug, your body will be more sensitive to light, so avoid direct sunlight as much as possible and use sunscreen and smoked glasses.
This drug is hypnotic, so do not drive or work with equipment that requires caution until the effect of the drug is completely eliminated.
Indications for Trifluoperazine
This drug is used in the treatment of psychotic disorders.
Mechanism of action of Trifluoperazine
Antagonists for mesolimbic dopaminergic D2 receptors in the brain; Reduces the release of hormones from the hypothalamus and pituitary gland.
Pharmacokinetics of Trifluoperazine
Absorbed after oral administration but has the first hepatic metabolism. The maximum plasma concentration occurs 2-4 hours after oral administration. The drug is extensively metabolized in the liver and excreted mainly by the kidneys. The binding of this drug to plasma proteins is very high.
Contraindications to the use of Trifluoperazine
It should not be used in the presence of heart disease (more or less high blood pressure), severe CNS weakness, coma, congenital QT syndrome, a history of cardiac arrhythmias, and congenital genetic defects that reduce P4502D6 isoenzyme activity.
Side effects of Trifluoperazine
Cardiovascular: hypotension, postural hypotension
Central nervous system: decreased seizure threshold, dizziness, dysregulation of the body temperature, extra-pyramidal reaction (acacia or motor restlessness, dystonia, symptoms of false Parkinson’s, dyskinesia tardio or repeated involuntary movements), headache, malignant neuroleptic syndrome
Skin: skin discoloration (blue-gray), skin sensitivity to light, skin rash
Endocrinology and metabolism: changes in libido, changes in menstrual bleeding, galactorrhea, gynecomastia, hyperglycemia, hypoglycemia, weight gain
Gastrointestinal: constipation, nausea, stomach pain, vomiting, dry mouth
Genitourinary: difficulty urinating, abnormal ejaculation, milk production, breast pain, priapism, urinary retention
Hematology and oncology: agranulocytosis, aplastic anemia, increased eosinophil levels, hemolytic anemia, immunological thrombocytopenia (ITP), leukopenia, pancytopenia (reduction of all blood cells)
Hepatic: cholestatic jaundice, hepatotoxicity
Nervous, muscular and skeletal: Vibration
Ocular: Corneal changes, lens disorders, retinitis pigmentosa (retinal pigment inflammation)
Respiratory: nasal congestion
Drug Interactions Trifluoperazine
Category X Interactions (Avoidance)
Achlidinium, aminoluvinolic acid (systemic), amisulpride (oral), azlastine (nasal), bromoperide, bromoperidol, cimetropium, oxadolin, oleic acid (oral inhalation), glycopironium (topical), epiratropinum (topical), epi , Oxomazine, Paraldehyde, Pyrididyl, Potassium Chloride, Potassium Citrate, Rufenacin, Sakuinavir, Sulpiride, Thalidomide, Tiotropium, Omclidinium
Reducing the effects of drugs with trifluoperazine:
Acetylcholinesterase inhibitors, amphetamines, anti-Parkinson drugs (dopamine agonists), gastrointestinal drugs (gastrointestinal agents (prokinetic)), guanthidine, itopride, levosulpiride, nitroglycerin, pirigidol, pirigidil
Reducing the effects of trifluoperazine by drugs:
Acetylcholinesterase inhibitors, antacids, anti-Parkinson drugs (dopamine agonists), lithium, pyridabyl
Precautions Trifloprazine
This medicine should be used with extreme caution in the following cases:
Acute Calcium, Blood Dyskrasia, Severe Brain Injury, Atherosclerosis, Decreased cardiac stores such as mitral valve insufficiency, Cerebrovascular insufficiency, Pheochromocytoma, Kidney insufficiency, Reye syndrome, Sensitive liver failure
It is recommended to monitor abnormal movement and closely observe the early signs of dyskinesia regularly during treatment, especially in the elderly and patients receiving large amounts of medication.
Drug recommendations for Trifluoperazine
The course of treatment with this drug should be completed. This medicine should not be taken in excess of the prescribed amount.
It may take several weeks to achieve the desired therapeutic effects.
If a dose is missed, if the regimen is once a day, the missed dose should be taken as soon as it is remembered. Otherwise, the missed turn should be avoided. If the treatment regimen is several times a day, it should be taken as soon as it is remembered within an hour. Otherwise, the missed dose or doubling the next dose should be avoided.
You should see a doctor before stopping the drug. Gradual discontinuation of the drug may be necessary.
Alcohol-containing products and other CNS depressants should be avoided with this drug.
If you need any surgery or emergency treatment, your doctor should be aware of this medication.
Caution should be exercised when driving or operating machinery that requires alertness.
Caution should be exercised when waking up suddenly from a lying or sitting position.
When exercising, in hot weather or when bathing in hot water, caution should be exercised due to the possibility of heat shock.
This medicine may cause dry mouth. If the dryness persists for more than two weeks, you should see a doctor.
There is a possibility of photosensitivity with the use of this drug. Wearing goggles and protective clothing may be necessary
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