common name:








What is Sertraline?

Brain cells, called neurons, secrete different chemicals to communicate with other neurons. This means that a series of electrical impulses between neurons are responsible for the functions of different parts of the brain.
Serotonin is one of these chemicals that is produced in the brain. When serotonin is released from neurons, it stimulates other neurons, then is pumped back to the brain cells and recovered.
Sertraline belongs to the family of antidepressants, serotonin reuptake inhibitors (SSRIs), which are prescribed for a variety of disorders, including the treatment of depression, panic attacks, anxiety disorders, and obsessive-compulsive disorder.
Depression and panic attacks usually occur in people without a specific cause or as a result of communication problems, trauma or an illness.
Serotonin reuptake inhibitors (SSRIs), one of which is sertraline, increase serotonin levels in the space between neurons. This helps relieve depressive symptoms, panic attacks, and many other disorders. It is related to the mood in some people. Sertraline is also used to treat premature ejaculation due to decreased libido

It is used in the treatment of depression, obsessive-compulsive disorder, panic disorders and mood disorders
Mechanism of action of sertraline
Sertraline is a potent and selective inhibitor of SSRI serotonin reuptake and is enhanced by enhancing serotonergic activity in the CNS and subsequently inhibiting adrenergic activity in the Locus Coeruleus area.


Before taking sertraline

-Tell your doctor if you are pregnant, trying to conceive or breastfeed.
– If you have a history of liver, kidney, heart problems (irregular heartbeat), epilepsy, type 2 diabetes, eye problems (such as glaucoma or glaucoma), blood problems (bleeding), severe mood swings (sudden euphoria) be sure to see a doctor Inform yourself.
-If you are being treated with electric current (shock therapy) at the same time as prescribing this medicine, tell your doctor.
-Tell your doctor if you have a history of any drug allergies.
-If you have been taking antidepressants from the monoamine oxidase inhibitor group (such as selegiline, rasgelilin, tranylcypramine, etc.) in the last two weeks, be sure to remind your doctor.
-Because this drug can interfere with the function of other drugs in the body, it is necessary to give a list of all your medications to your doctor or pharmacist before taking (especially heart medications, antiepileptics, antibiotics). And antifungals and sedatives)

How to take sertraline

– This drug is available in the form of tablets and capsules of 50 and 100 mg.
-Because this drug affects the nervous system, it should be taken regularly and under the supervision of a doctor. Although you may not feel better in the first few weeks of treatment, still continue your treatment and according to See your doctor regularly and also ask your doctor or pharmacist any questions you may have about improving your treatment.
Discontinuation of this drug suddenly and without a doctor’s opinion can have adverse effects on the patient, including a seizure, so discontinuation of this drug should be done gradually and under the supervision of a physician.
– Your doctor may start treatment with a small amount of medication and after your body gets used to it, increase the amount of your medication to reduce the risk of side effects from the medication.
-If this medicine is prescribed for you in 1 dose per day, you can take it at any time of the day when you are comfortable. But set a specific time for all days and take the medicine regularly. It is usually recommended to be consumed this morning or evening.
-If you are taking this medicine to treat anxiety disorders, your doctor may start treatment with a small amount of the medicine. For this reason, it is better to start the drug with a small amount and gradually increase the dose, so take this drug exactly according to the doctor’s instructions and pay attention to the emphasized dose.
-This medicine does not interfere with food and can be taken before or after food.
-If you miss a dose, take it immediately, but strongly avoid doubling the dose at one time.

Sertraline drug recommendations

You may not see any signs of improvement in the first 2-3 weeks of treatment with this drug, however, continue to take the drug.
During treatment with this drug, be under the supervision of a doctor to check the progress of your treatment.
At the beginning of treatment with this drug, you may have more disturbing thoughts than before, but do not worry. You should know that these thoughts are caused by taking this drug and starting its effectiveness and will disappear over time.
In these cases, it is better to share your thoughts with your relatives or your counselor and doctor and take action to resolve them consciously.
Consumption of grapefruit or grapefruit juice in the diet increases the risk of sertraline side effects, so limit the consumption of this food in your diet.
Consumption of alcohol during treatment with this drug can increase the likelihood of side effects from this drug.
If you have diabetes, it is more important to check your blood sugar daily than before because this medicine can change your blood sugar level. If this problem occurs, get the necessary advice from your doctor. .
Before taking or starting any medication, herbal product or supplement, especially anti-inflammatory and analgesic drugs, tell your doctor or pharmacist about taking sertraline to prevent drug interactions.
Taking antidepressants and carbamazepine with this drug requires a doctor to review and adjust the appropriate dose.
There are various antidepressants with different effects. If you feel that this medicine is not suitable for you, you can talk to your doctor about changing the medicine, but avoid stopping treatment.
During treatment with this drug, your body will be more sensitive to light, so avoid exposure to direct light and use sunscreen and sunglasses.

Common side effects of Sertraline

Gastrointestinal side effects such as nausea, indigestion, constipation or diarrhea are especially common at the beginning of sertraline consumption, which can be reduced by consuming simple and light meals and drinking enough water.
If you feel drowsy, weak and tired, avoid driving and doing things that require caution and concentration.
Ask your pharmacist about the right painkiller for possible headaches from taking this medicine.
Dry mouth is also one of the symptoms related to the use of this drug, which can be eliminated with chewing gum or sugar-free candy.
Mood swings, such as anxiety, distress, restlessness, and tremors, may occur early in treatment with sertraline, which resolve over a period of days, but talk to your doctor if these symptoms persist or worsen. .
Talk to your doctor if you have trouble sleeping, excessive sweating, loss of appetite or sudden weight change, pain, tingling sensation, sexual problems, ringing in the ears, irregular heartbeat, runny nose or itching that persists.

Side effects of sertraline

Gastrointestinal: diarrhea, nausea, dry mouth
Nervous system: dizziness, drowsiness, fatigue, insomnia

Rare but important side effects

Serotonin syndrome, or serotonin intoxication, is a specific complication of drugs that affect serotonin levels and, although unlikely to occur, can be life-threatening if left untreated.
This complication is caused by excessive activity of serotonin in the body. If you notice symptoms such as burning sensation, sweating, insomnia and restlessness, muscle stiffness or cramps, anxiety and mood swings immediately before taking the dose. Next, see your doctor or health center for this medicine.
If you have symptoms of drug allergies such as red and itchy skin lesions, shortness of breath, swelling of the face or lips, stop taking the medicine and see a doctor or medical center.

Pharmacokinetics of sertraline

Sertraline is slowly absorbed through the gastrointestinal tract and its maximum plasma level is 4.5-8.5 hours after ingestion. Metabolism has a large first pass in the liver. The main ways of its main metabolism are demethylation and its conversion to dimethyl sertraline, which is inactive. Widely distributed in all tissues of the body and has 98% protein band. Its elimination half-life is about 26 hours. It is excreted in equal amounts in urine and feces, which is mainly in the form of metabolites. This drug also enters breast milk.

Cardiovascular: edema, hypertension, palpitations, syncope, tachycardia, vasodilation
Skin: Hair loss, dermatitis bellows, dermatitis, hyperhidrosis, erythematous rash, follicular rash, hyperhidrosis, maculopapular rash, pruritus, urticaria
Endocrinology and Metabolism: Decreased libido, diabetes mellitus, unrelated galactorrhea, hypercholesterolemia, hypoglycemia, hypothyroidism, weight loss
Gastrointestinal: Abdominal pain, bruxism, constipation, loss of appetite, indigestion, hematochezia (increased bloody stools), increased appetite, melena (dark bloody stools), vomiting
Genitourinary: defects in ejaculation, ejaculation disorders, erectile dysfunction, blood in urine, priapism, sexual disorders (men), urinary incontinence, vaginal bleeding
Hematology and oncology: bleeding, rectal bleeding
Liver: Increased liver enzymes
Hypersensitivity: Anaphylaxis
Nervous system: gait disturbance, agitation, anxiety, ataxia, coma, confusion, euphoria, hallucinations, hypertension, hypostasis (impaired sense of touch), impaired consciousness, irritability, lethargy, lethargy, psychomotor agitation, seizures, yawning
Neuromuscular and musculoskeletal: Muscle hyperkinesia, muscle spasm, tremor
Eye: Blurred vision, pupil dilation, visual disturbance
Ear: tinnitus
Respiratory: Bronchospasm
Nervous system: aggressive behavior
Nervous, musculoskeletal: joint pain, muscle spasms
Respiratory: nosebleed
Miscellaneous: Fever

Category X Interactions (Avoidance)

Bromoperide, dapoxetine, disulfiram, linzolid, methotrexate, methylene blue, monoamine oxidase (antidepressant) inhibitors, pimozide, rasagilin, seleglin, urokinase

Food interference
has not been stated.

Sertraline warnings

In patients with hepatic or renal impairment – Heart disease – History of seizures – Coagulation disorders – Closed-angle glaucoma and a history of mania should be used with caution, In patients with hepatic impairment dose reduction should be considered.
Safety and effectiveness of sertraline in children for the treatment of depression – Panic disorders – PTSD cases and social anxiety disorders have not been proven


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