wat is Prednisolone?
Prednisolone belongs to the group of corticosteroid drugs. Corticosteroids are prescribed in many cases. For example, they are used to control the symptoms of asthma, intestinal inflammation and autoimmune diseases (such as lupus), joint and muscle diseases (such as rheumatism) and allergies.
These drugs are also prescribed to treat some cancers.
Corticosteroids reduce inflammation and inflammation by suppressing the immune system in the body.
Before taking Prednisolone
Tell your doctor if you are pregnant, trying to conceive or breastfeed.
If you have a history of high blood pressure, heart attack or any cardiovascular problems, liver disorders, diabetes, high blood pressure (glaucoma or glaucoma), osteoporosis, hypothyroidism, mental illness (such as depression) And psychosis), epilepsy, peptic ulcer and inflammatory bowel disease be sure to inform your doctor.
Tell your doctor if you have recently been vaccinated or plan to get vaccinated.
Tell your doctor if you already have or have had an infection.
Tell your doctor if you are in contact with people with infectious infections such as chickenpox, measles and shingles.
Tell your doctor if you have a history of vascular blockage or blood clots in your arteries.
-Because this drug can interfere with the function of other drugs in the body, it is necessary to provide a list of all your drugs to your doctor or pharmacist before taking.
Be sure to tell your doctor if you have a history of any drug allergies or muscle pain after taking corticosteroids (dexamethasone, betamethasone , etc.).
Taking prednisolone for children
Prednisolone should not be used in children under 3 years of age. Its consumption in children reduces growth. In children over three years of age, this drug should be taken in low doses under the supervision of a physician.
Common side effects of Prednisolone
Although the use of this drug is vital for many diseases and its benefits are more and more valuable for the patient, but a variety of drug side effects can be caused by the use of this drug, if followed by the recommendations of your doctor and pharmacist and Regular follow-ups can control them.
Gastrointestinal side effects such as heartburn, indigestion or nausea with oral corticosteroids are very common and can be reduced by taking medication with or after a light meal and avoiding high-fat and spicy foods. But if the nausea and vomiting continue and the vomit contains blood, you must see your doctor.
Changes in mood and behavior, especially at the beginning of treatment, may occur. Talk to your doctor or counselor about your thoughts and concerns.
Be sure to talk to your doctor if you have trouble sleeping, feeling dizzy, have an infection, muscle weakness, fatigue, or irregular menstruation.
Long-term use of prednisolone requires appropriate follow-up, blood tests, bone tests, etc. periodically to prevent or control the side effects of long-term use of these drugs, so if this drug It has been prescribed for you for a long time, do not disconnect from your doctor.
How should Prednisolone be used?
You must follow the instructions on the medicine label. Your doctor can also change the dose on these labels and never lower or lower the dose of this medicine on your head. This medicine is sometimes given every other day.
The dose of liquid medicine is usually measured with a medicine spoon or cup. If you do not have these measuring spoons, be sure to get one from a pharmacy.
You should shake the medicine well before measuring the dose. Then follow the instructions on the label.
For all kinds of pills, you have to open the box or can with a dry hand and take it out of the foil. If you have trouble swallowing, use the syrup.
You should change the dose if you have problems such as a serious illness, fever, surgery or infection.
You should not stop taking this medicine suddenly.
You should take each medicine on time because a bit of delay can change the result of this medicine or delay the treatment.
If people have surgery, your doctor may stop taking this medicine for a short time.
This medicine should be stored at room temperature away from moisture and heat.
Mechanism of action of Prednisolone
The drug crosses the cell membrane and binds to its receptors in the cytoplasm, and the receptor drug complex enters the cell nucleus. This complex binds to specific regions of DNA and stimulates the mRNA transcription process, then the enzymes that are responsible for the systemic effects of corticosteroids are made.
The effect of corticosteroids on inflammation is that they prevent the accumulation of inflammatory cells in the area of inflammation and inhibit phagocytosis and release chemical mediators of inflammation.
What to do if you forget to use Prednisolone?
In these cases, never do it yourself and call your doctor.
What happens if this drug is overdosed?
Overdosing of this drug is not considered a threat to life. However, long-term use of high-steroid medications can cause symptoms such as thinning of the skin, bruising, changes in the shape or location of body fat, especially on the face, neck, back, increased acne and facial hair, menstrual problems, impotence in Men and sexual reluctance to follow.
What should I avoid while taking this medicine?
You should not get the live vaccine while taking prednisolone. This vaccine does not work well when you are taking this medicine and does not protect you from the disease, so you should avoid approaching sick and infected people.
Side effects of Prednisolone
- Shortness of breath even in mild cases, swelling, rapid weight gain.
- Bruising, thinning of the skin or any wound that does not heal.
- Severe depression, changes in personality, unreasonable thoughts and behavior.
- New or unusual pain in the arm, leg and back.
- Bloody or tarry stools, bloody coughs or vomits that look like coffee beans.
- Severe upper abdominal pain, nausea and vomiting.
- Muscle contraction, potassium deficiency, constipation, irregular heartbeat, chest pain, frequent urination, numbness or tingling.
- Get angry fast.
- Blurred vision.
- Severe decrease in urine
- Change the mood
- Difficulty talking, thinking and walking.
- Darkening of the skin
- Dry mouth
- Many tears
- Increased hunger
- Lack of appetite
- Redness of the skin
- Unexpected weight loss
- Dry scalp
- Redness of the face
Other side effects of Prednisolone
- Swelling of hands and feet.
- Changes in menstruation.
- Muscle pain and weakness.
- Stomach problems and bloating.
What other medications can affect the process and effectiveness of Prednisolone?
- Medications that react with prednisolone include vitamins and herbal products.
- Concomitant use of prednisolone with anticoagulants reduces the effects of these drugs.
- Concomitant use of prednisolone with barbiturates, ephedrine and phenytoin increases the clearance of hydrocortisone.
- Concomitant use of prednisolone with estrogen enhances the effect of hydrocortisone.
- Concomitant use of prednisolone with ketoconazole and macrolide antibiotics reduces the clearance of hydrocortisone.
- Concomitant use of prednisolone with NSAIDs may increase the gastrointestinal side effects of the drug.
- Concomitant use of prednisolone with amphotericin B, carbicillin, pipracillin, t-carcillin or diuretics may cause severe hypokalemia.
- Concomitant use of prednisolone with cardiac glycosides increases cardiac glycoside intoxication.
- Concomitant use of prednisolone with insulin increases the need for insulin.
- So inform your doctor about any medicine you are taking now and in the past.
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