Oxytip Usage
Oxytip is used to induce exacerbation of uterine contractions during childbirth, prevention and treatment of postpartum hemorrhage, treatment of incomplete and therapeutic abortions, reduction of milk outflow, diagnosis of fetal distress and diagnosis of uterine-placental insufficiency.
Oxytip Mechanism of action
The uterus contains Oxytip-sensitive receptors. Oxytip stimulates uterine smooth muscle contraction by increasing the concentration of intracellular calcium, and thus, by mimicking normal contractions, induces labor and temporarily slows uterine blood flow. The intensity and extent of uterine contractions increase, leading to dilation and disappearance of the cervical membrane. As pregnancy progresses and the number of oxytocin receptors increases, the uterine response to Oxytip also increases.
Oxytip Pharmacokinetics
Drug metabolism is mediated by tissue Oxytip. Oxytip is also present in placenta and plasma. The half-life of the drug is 1-6 minutes. In intramuscular injection, the effect of the drug is after 3-5 minutes and the duration of the effect of the drug is 2-3 hours, and in intravenous injection, the onset of action is immediate and the duration of the effect is one hour.
Oxytip Contraindications
In the presence of hypertensive uterine contractions, mechanical obstruction to delivery, fetal problems, conditions in which vaginal delivery should not take place, uterine resistance to Oxytip, severe preeclampsia or severe cardiovascular disease, and severe renal insufficiency in women. 35 years and women with a history of cesarean section should not be used.
Oxytip Side Effects
Cardiovascular: Cardiac arrhythmia, hypertensive crisis, hypotension, subarachnoid hemorrhage, tachycardia, premature ventricular contractions
Endocrinology and metabolism: Water poisoning (severe water poisoning with seizures and coma following a gentle infusion of oxytocin within 24 hours).
Gastrointestinal: nausea, vomiting
Genitourinary: Postpartum hemorrhage, uterine rupture
Hematology and oncology: Pelvic hematoma
Hypersensitivity reaction: Anaphylaxis
Oxytip Drug Interactions
Exacerbation of hyponatremia
Category X Interactions (Avoidance)
Carboprost Trometamine, Jumprost
Reduction of the effects of drugs by Oxytip:
No significant interference has been identified.
Reducing the effects of Oxytip by drugs:
No significant interference has been identified.
Increased effects of drugs by Oxytip:
Ephedrine (nasal and systemic), haloperidol, QT prolongation agents (highest risk)
Enhancing the effects of Oxytip by drugs:
Carboprost Trometamine, Dinoprostone, Gemprost, Misoprostol
Oxytip Warnings
- In case of mismatch between the fetal head and the mother’s pelvis, induction of labor should be done with caution.
- In mild or moderate hypertension caused by pregnancy and cardiovascular disease, the drug should be used with caution.
- In case of water poisoning and hypoglycemia, infusion of large volumes of fluids should be avoided.
- The effects of the drug are increased by concomitant administration of prostaglandins and careful patient control is required.
- In caudal obstruction anesthesia, the antihypertensive effects of sympathetic mimics may be exacerbated.
Oxytip Medication recommendations
- By closely monitoring the fetal heart rate and uterine activity, the amount of medication can be adjusted to suit each individual’s needs. The drug should be discontinued if there is an increase in uterine activity or fetal abnormalities.
- Rapid intravenous injection of the drug should be avoided.
- Long-term administration of large amounts of the drug, along with intravenous injections of large volumes of fluids, may cause water poisoning and hypotension. Therefore, electrolyte-containing diluents should be used to increase oxytocin concentrations and limit fluid intake.
- Do not prescribe oxytocin if other oxytocic drugs are used concomitantly until their effects are reduced.
Pharmaceutical and generic forms
OXYTIP 10U/1ML AMP
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