uses of valproate

Orlpet or sodium valproate is one of the most important and effective drugs for controlling seizures of epilepsy at all ages.

  1. Bipolar disorders
  2. Migraine prevention
  3. Treatment of nerve pain
  4. Personality disorders
  5. Neurological diseases such as depression
  6. Nervous pain caused by diabetes
  7. Mania treatment

Side effects of taking sodium valproate

Sodium valproate or Orlpet tablets, like any other medicine, may have side effects.
Side effects of overlap include the following:

 1 .Central nervous system (CNS) complications

Complications of overlap on the nervous system include:

Ataxia (irregularity or irregularity of muscle movements)
Imbalance and tremor

 2 .Gastrointestinal (GI) Complications

Side effects of Orlpet on the gastrointestinal tract include:

Abdominal pain
Weight gain or loss

 3 .Cardiovascular Complications (CV)

Cardiovascular complications of sodium valproate include:

Chest pain
Lower blood pressure
increase of heart rate

 4 .Ear, nose, throat and eye (EENT) complications

Sodium valproate also has side effects on the ears, throat, nose and eyes:

Blurred vision
Nystagmus (repetitive and involuntary eye movements)
Rhinitis (inflammation of the nasal mucosa)
Pharyngitis (inflammation of the throat)

 5 .Respiratory Complications (Resp)

Respiratory side effects include other side effects of Orlpet:

Bronchitis (inflammation of the bronchi)
Shortness of breath

 6 .Skin Dermis

Sodium valproate tablets also have side effects in some cases:

Alopecia (hair loss)
Erythema multiforme

 7 .Other complications

Other side effects that Orlpet tablets can cause include:

Liver toxicity
Bone marrow suppression
Petechiae (bleeding spots under the skin)
Increased blood ammonia concentration
Decreased blood platelets
Reduction of white blood cells
Irregular menstruation
Gynecomastia (breast enlargement in men)

Contraindications to sodium valproate (contraindication)

Sodium valproate, or Orlpet, can be deadly! Therefore, be sure to consult a doctor before use.

Also, people who have the following options should avoid taking sodium valproate (unless your doctor tells you to):

If you are hypersensitive to the drug
Having urea cycle disorders
Patients with mitochondrial disorders

Valproate drug interactions

Valproate increases the drug concentration of the following drugs:


Antidepressants and antipsychotics counteract the anticonvulsant effect of this drug by lowering the seizure threshold.

Cimetidine increases the plasma concentration of valproate by inhibiting liver enzymes.

Chloroquine counteracts the anticonvulsant effect of this drug.

Concomitant administration of antiepileptic drugs increases drug toxicity; Without increasing its therapeutic effects.

Taking valproate with diazepam inhibits diazepam metabolism.

Carbamazepine may decrease carbamazepine levels and increase its metabolite levels.

Concomitant use of aspirin with valproate reduces protein binding and inhibits valproate metabolism, thereby increasing its blood concentration.

Valproate use during pregnancy

The drug should not be used in women who are planning to become pregnant because of the potential for decreased IQ and severe congenital disorders (such as neural canal defects) that may occur very quickly.
Important: This drug is also in group D during pregnancy, which means that it is dangerous for the human fetus and can be used only if the doctor prefers the benefits of this drug.

Valproate poisoning and treatment

Symptoms of intoxication include heart block, drowsiness, and coma. Treatment for intoxication is supportive. Naloxone relieves central nervous system weakness but may also reduce the anticonvulsant effects of the drug.


Liver function should be monitored before starting treatment and during the first 6 months of treatment with this drug.

In case of severe renal insufficiency, systemic lupus erythematosus or porphyria should be used with extreme caution.

Liver dysfunction (including fatal liver failure) with this drug may occur in children under 3 years of age, people with metabolic or degenerative disorders, in a state of organic brain disorder or severe seizures with mental retardation.

Care should be taken in case of acute abdominal pain that may be a sign of pancreatitis.

If you are pregnant or breastfeeding, have a history of liver or kidney problems, blood clots, and if you have lupus, be sure to tell your doctor before taking this medicine.

Avoid abrupt discontinuation or changing the dose of the drug.

Do not drink alcohol while taking this medicine.

Avoid breaking the tablets due to mucosal irritation and in case of gastrointestinal irritation, this drug should be taken with food but not with carbonated drinks.

Consult your doctor if you experience symptoms of liver disorders such as loss of appetite, pain in the upper part of the stomach (it may also shoot in the back), nausea, vomiting, dark urine, pale stools, swelling of the face or jaundice.



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