What is Naproxen Pill?
Naproxen belongs to a group of drugs known as corticosteroid-free anti-inflammatory drugs. Naproxen is used to relieve pain such as arthritis (inflammation of the joints), muscle spasms or bruises, back pain, gout and menstrual cramps. This group of drugs is called NSAIDs.
This medicine helps to improve the patient’s condition by reducing inflammation and relieving pain.
By blocking the effect of cyclooxygenase, naproxen reduces the production of a chemical called prostaglandin in the body, which is responsible for causing pain and inflammation in the affected area. Inflammation is reduced.
Naproxen in Corona
Although naproxen can be used for pain caused by the coronavirus, some doctors believe that drugs such as naproxen and ibuprofen may exacerbate the symptoms of Covid 19, so the World Health Organization (WHO) has recommended that ibuprofen be taken until clinical results are obtained. And naproxen should be avoided in patients with Quid 19.
Before taking Naproxen
Tell your doctor if you are pregnant or breastfeeding so that he or she can prescribe the appropriate medication for your condition.
Tell your doctor if you have a history of asthma, allergies, stomach or duodenal ulcers, and gastrointestinal diseases (such as Crohn’s disease), cardiovascular disease, lupus, liver, kidney problems, Parkinson’s disease, epilepsy, and more.
Tell your doctor if you have a history of high blood pressure or blood clots in your arteries.
-Because this drug can interfere with the action of other drugs in the body, it is necessary to provide a list of all your medications to your doctor or pharmacist before taking.
Tell your doctor if you have a history of allergies to painkillers (such as aspirin, indomethacin, celecoxib, ibuprofen, etc.).
Tell your doctor if you have a history of high blood sugar or cholesterol.
– In people over 65 years of age, this drug should be used with extreme caution and under the supervision of a physician.
Tell your doctor if you are a smoker.
Specific recommendations for Naproxen tablets
In case of digestive problems, take the medicine after food.
Take the medicine with 2 glasses of water.
Periodic tests prescribed by your doctor are required for you.
– This drug has drug interactions with alcohol and smoking.
Do not take more than the amount recommended by your doctor.
Use with caution in the elderly.
Tell your doctor if you have a heart or respiratory problem.
– If you see signs of severe inflammation of the skin, mouth or eyes, blackening of the stool, etc., stop taking the drug immediately and see a doctor.
Side effects of Naproxen tablets
Gastrointestinal symptoms such as indigestion, heartburn, stomach pain, etc. are common symptoms of NSAIDs that are recommended to be taken after meals to reduce them. If these side effects persist, consult your doctor.
To improve diarrhea caused by taking this drug, it is recommended to consume simple meals and enough fluids.
In case of constipation, a diet rich in fiber (fruits and vegetables) and adequate fluid intake are recommended.
The feeling of nausea caused by this drug is reduced by consuming light meals and avoiding high-fat and spicy foods.
See your doctor if you have breathing problems, or any symptoms of drug allergies (such as swelling of the face and mouth).
If you notice blood or dark stools, vomiting containing blood or severe abdominal pain, stop taking the medicine and see your doctor.
The above are the side effects of naproxen that are more likely to occur and there may be other side effects that are less common.
Naproxen 250,Naproxen 500
Naproxen 250 is actually the weakest dose of this drug, which is mostly used in mild pain such as normal headaches and as a fever reliever, and to prevent gastrointestinal complications, it is better to take it after a meal, and taking this drug with other painkillers is not recommended. Naproxen 500 tablets are used in cases of severe pain due to its high dose and it must be taken after a meal. In heart patients, it must be used with a doctor’s opinion. Naproxen 500 tablets are not recommended for long-term use
Contraindications to Naproxen
This drug is strictly forbidden in the third trimester of pregnancy and is classified as a group X drug and may lead to death or organ failure.
Side effects of Naproxen
- Cardiovascular: edema, palpitations
- Central nervous system: dizziness, drowsiness, headache
- Skin: itching, skin rash, bruising, increased sweating
- Endocrinology and metabolism: water retention, thirst
- Gastrointestinal: Abdominal pain, constipation, nausea, heartburn, diarrhea, indigestion, inflammation of the mouth, bloating, gastrointestinal bleeding, gastrointestinal perforation, gastrointestinal ulcer, vomiting
- Hematology and oncology: hemolysis, purpura, anemia, increased bleeding time
- Liver: Increased liver enzymes
- Ocular: Visual disorders
- Ear: tinnitus, hearing impairment
- Renal: Abnormal renal function
- Respiratory: Shortness of breath
Naproxen drug interactions
P-gp inhibitor (weak)
Nephropathy caused by painkillers
Intensification of antiplatelet effects
Decreased perfusion or renal function
Increased risk of bleeding or damage to the gastrointestinal mucosa
Exacerbation of hyperkalemia
Intensifying the antihypertensive effects
Exacerbation of hyponatremia
Decreased seizure threshold
– Increased phone toxicity
Category X Interactions (Avoidance):
Asmethicacin, Aminoluvinolic acid (systemic), Dex ibuprofen, Dex ketoprofen, Fluctafenine, Ketorolac (systemic and nasal), Massimurlin, Mifamortid, Morniflumate, Nonsteroidal anti-inflammatory drugs (NSAIDs), Phenoxaphenate Zaltoprofen
Reducing the effects of drugs by naproxen:
Aliskiren, angiotensin II receptor blockers, angiotensin converting enzyme inhibitors, beta-blockers, apleronone, hydralazine, loop diuretics, massimorlin, mifamortid, potassium-sparing diuretics, seroconazole, prostaglandin (prostaglandin) And thiazide-like diuretics
Reducing the effects of naproxen by drugs:
Bile complexing agents, salicylates
Increased effects of drugs by naproxen:
5-Aminosalicylic acid derivatives, antiplatelet drugs, aliskiren, aminoglycosides, aminoluvinolic acid (topical and systemic), anticoagulants, apixaban, bemiparin, bisphosphonate derivatives, cephalostecate, cephalospirate, ciplastec , Defrasirox, deoxycholic acid, desmopressin, dex ibuprofen, digoxin, drospirenone, adoxaban, enoxaparin, apleronone, haloperidol, heparin, ibritomob thiocestane, lithium, CO2, anti-methotrexate Potassium-containing preservatives, paralaterexate, quinolones, rivaroxaban, salicylates, tacrolimus (systemic), tenofovir products, thrombolytic drugs, tolperisone, urokinase, vancomycin, vertporphine, antagonists
Increased effects of naproxen by drugs:
Acalabrotinib, Ashemetasine, Alcohol (ethyl), Angiotensin II receptor blockers, Angiotensin converting enzyme inhibitors, Systemic corticosteroids, Cyclosporine (systemic) Fluctafenine, glucosamine, herbs (with antiplatelet and anticoagulant properties), ibrotinib, inotersen, ketorolac (systemic and nasal), limaprost, loop diuretics, morneflumate, multivitamin / fluoride (containing vitamins A, di, / Mineral (contains vitamins A, D, E, K, folate and iron), multivitamins / Mineral (contains vitamins A and E, no iron), naphthazone, omega-3 fatty acids, plubiprofen, pentosan sodium polysulfate, pentoxifylline Phenylbutazone, probenecid, prostacyclin analogues, serotonin reuptake inhibitors, solometinib, norepinephrine / serotonin reuptake inhibitors, sodium phosphate, talniflumate, tenoxicam, thiazide and thiazide-like diuretics , Vitamin E (systemic), Zaltoprofen, Zanobrotinib
The rate and amount of naproxen absorption may be reduced if taken with food.
Solution: To reduce gastrointestinal side effects, consume with food, milk or antacids.
This medicine should be used with extreme caution in the following cases:
Inflammatory or ulcerative disease of the upper or lower ear canal (including Crohn’s disease, diioticitis, gastrointestinal ulcer, osserative colitis), hemophilia or other blood disorders including coagulation or platelet dysfunction, kidney failure, kidney disease, salivary gland disease Patients at high risk of bleeding and peptic ulcer: bleeding from the rectum and anus, hemorrhoids, inflammation and lesions of the rectum and anus and inflammation of the rectum.
Naproxen drug recommendations
- This medicine should not be taken more than the recommended amount.
- If this drug is used to treat arthritis, the course of treatment should be complete. It may take at least 2 weeks to achieve the desired response.
- If you miss a dose, if the treatment regimen is one or two pills a day, if you remember within an hour or two after the missed dose, that dose should be taken. If the treatment regimen is more than two pills a day, that dose should be taken as soon as you remember, unless it is almost time for your next dose. The next dose should not be doubled.
- The drug is best taken with food to reduce gastrointestinal irritation.
- Regular visits to the doctor in case of long-term use are recommended to check the progress of treatment.
- There is a possibility of photosensitivity.
- See your doctor if you have flu-like symptoms (chills, fever, or muscle aches) before or at the same time as the rashr.
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