Metopamid - FireDrug

Indications Metopamid

Metoclopramide is used to treat nausea and vomiting caused by surgery or chemotherapy, return of stomach contents to the esophagus, slow gastric emptying, prevention of aspiration pneumonia, vascular headache, persistent hiccups, and diabetic gastric paralysis.

Mechanism of action Metopamid

Metoclopramide may inhibit dopamine-induced gastric smooth muscle relaxation and thus potentiate cholinergic effects. The antiemetic effects of the drug are due to the increase in the activity threshold of chemical receptors (CTZ).

Pharmacokinetics Metopamid

Metoclopramide is rapidly absorbed from the gastrointestinal tract. Its metabolism is hepatic and the half-life of the drug is 4-6 hours. The starting time of the drug is 30-60 minutes orally, 10-15 minutes intramuscular injection and 1-3 minutes intravenous injection. The duration of action of the drug is 1-2 hours and its excretion is mainly renal.

Contraindications Metopamid

Should not be used if the patient has epilepsy, gastrointestinal bleeding, mechanical obstruction or perforation of the gastrointestinal tract or pheochromocytoma.

Precautions Metopamid

In case of severe renal or hepatic impairment, it should be used with caution. In case of severe renal or hepatic impairment, the dose should be reduced by about half. Extrapyramidal complications may occur in children and the elderly.

Side effects Metopamid

Changes in blood pressure, tachycardia, extrapyramidal effects and dyskinesia, diarrhea, dizziness, restlessness, fatigue or abnormal weakness are some of the side effects of the drug.

zrug interaction Metopamid

Metoclopramide with other CNS depressants aggravates the sedative effects of the drug.

Recommendations Metopamid

Intravenous injection of metoclopramide should be done slowly over 1-2 minutes. The oral form of the drug should be taken 30 minutes before each meal and at bedtime.

Dosage Metopamid

Adults: For the treatment of gastric paralysis caused by diabetes, 10 mg is taken up to 4 times a day, 30 minutes before the onset of symptoms or before meals and at bedtime. In the treatment of gastric contents returning to the esophagus, 10-15 mg is taken 30 minutes before the onset of symptoms or before meals and at bedtime, up to a maximum of 4 times a day. In the treatment of hiccups, the amount of 10-20 mg is prescribed 4 times a day for a week. If necessary, the initial amount of 10 mg is administered by intramuscular injection. The maximum dose is 0.5 mg / kg / day.
Children: In the treatment of delayed gastric emptying or as a peristaltic stimulant in children 5-14 years, the amount of 2.5-5 mg 3 times a day 30 minutes before meals and at bedtime is prescribed.
Adult injection: 10 mg intravenously in the treatment of gastric delay or peristaltic stimulus. In the treatment of hiccups, first 10 mg is slowly injected intravenously. And then continues orally. As an antiemetic in chemotherapy, 2 mg / kg is prescribed for 30 minutes before chemotherapy, which is repeated every 2 or 3 hours if necessary. If necessary, 1 mg / kg of the drug can be administered by intravenous infusion. As an antiemetic after surgery, 10-20 mg is given by intramuscular injection near the end of surgery.
Children: As an anti-nausea and in the treatment of gastric delay or peristaltic stimulant, 1 mg / kg is prescribed as a single dose, which is repeated if necessary one hour later.

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