Metoclopramide is used to treat nausea and vomiting caused by surgery or chemotherapy, return of stomach contents to the esophagus, slow gastric emptying, prevention of aspiration pneumonia, vascular headache, persistent hiccups, and diabetic gastric paralysis.
Mechanism of action Metopamid
Metoclopramide may inhibit dopamine-induced gastric smooth muscle relaxation and thus potentiate cholinergic effects. The antiemetic effects of the drug are due to the increase in the activity threshold of chemical receptors (CTZ).
Metoclopramide is rapidly absorbed from the gastrointestinal tract. Its metabolism is hepatic and the half-life of the drug is 4-6 hours. The starting time of the drug is 30-60 minutes orally, 10-15 minutes intramuscular injection and 1-3 minutes intravenous injection. The duration of action of the drug is 1-2 hours and its excretion is mainly renal.
Should not be used if the patient has epilepsy, gastrointestinal bleeding, mechanical obstruction or perforation of the gastrointestinal tract or pheochromocytoma.
In case of severe renal or hepatic impairment, it should be used with caution. In case of severe renal or hepatic impairment, the dose should be reduced by about half. Extrapyramidal complications may occur in children and the elderly.
Side effects Metopamid
zrug interaction Metopamid
Children: In the treatment of delayed gastric emptying or as a peristaltic stimulant in children 5-14 years, the amount of 2.5-5 mg 3 times a day 30 minutes before meals and at bedtime is prescribed.
Adult injection: 10 mg intravenously in the treatment of gastric delay or peristaltic stimulus. In the treatment of hiccups, first 10 mg is slowly injected intravenously. And then continues orally. As an antiemetic in chemotherapy, 2 mg / kg is prescribed for 30 minutes before chemotherapy, which is repeated every 2 or 3 hours if necessary. If necessary, 1 mg / kg of the drug can be administered by intravenous infusion. As an antiemetic after surgery, 10-20 mg is given by intramuscular injection near the end of surgery.
Children: As an anti-nausea and in the treatment of gastric delay or peristaltic stimulant, 1 mg / kg is prescribed as a single dose, which is repeated if necessary one hour later.
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