What is Livergol?
Effective in the treatment of fatty liver and hepatitis, a powerful antioxidant
Directions:
Take two tablets (Livergol 70 mg, Livergol 140mg) 3 times a day. The duration of use is at least two months.
side effects
Studies on the amount of silymarin in the blood of 3,500 patients have shown that the side effects seen in these patients include only very minor gastrointestinal disorders. A mild laxative effect can usually be seen with this medicine.
Use during pregnancy and lactation
So far, no side effects have been reported from taking this drug during pregnancy and lactation.
Pharmacological effects
Silymarin is a collection of polyphenolic compounds of St. John’s wort. The use of this plant for liver problems has a long history and now with extensive studies, these effects have been proven. Silymarin acts as a powerful and direct antioxidant and eliminates toxic free radicals. Increases intracellular glutathione and superoxide dismutase. Inhibits the formation of leukotrienes and increases the activity of RNA polymerase enzyme in the cell nucleus, stimulating the synthesis of ribosomal proteins, which in turn increases the ability of liver cell regeneration.
Silymarin is effective in treating both acute and chronic viral hepatitis. In a study of 29 patients with viral hepatitis treated with silymarin, it was shown that silymarin had a significant effect on elevated parameters such as serum bilirubin and liver enzymes compared with placebo. Laboratory parameters in the silymarin-treated group significantly returned to normal after two weeks of treatment compared with the placebo group. In a study of patients with chronic hepatitis virus, silymarin improved significantly. Consumption of 420 mg of silymarin in acute cases for 3-12 months has led to the improvement of liver cell lesions.
Blood protein levels increased and liver enzymes decreased. The usual symptoms of hepatitis (such as abdominal pain, loss of appetite, and fatigue) all improved. The invivo, invitro scientific study shows that silymarin, and especially the slap between the liver, protects against oxidative stress and inhibits inflammatory processes stimulated by free radicals and secondary cytokines.
Oxidative stress and inflammation have been shown to be involved in cellular lesions of many tissues and lead to tissue reactions in patients treated with anticancer drugs. The protective effects of silymarin and silybin in different tissues suggest the clinical use of these substances in combination with anti-cancer drugs to reduce their toxic effects in cancer patients.
Treatment of liver diseases
-Stimulation of DNA polymerase
– Cell membrane stabilization
– Inhibition of free radicals
– Increasing the concentration of cellular glutathione shows the effect of liver protection. Stimulation of DNA polymerase by silymarin increases ribosomal RNA synthesis and thus regenerates liver cells. Increasing the concentration of cellular glutathione also stabilizes superoxide dismutase and cellular glutathione peroxidase. Silymarin also reduces hepatitis by inhibiting the lipoxygenase-5 (lipoxygenase-5) cycle and inhibiting the production of leukotriene and free radicals in rat liver cells.
Improve the immune system
Silymarin affects the motility of unstimulated neutrophils and their chemotactic and phagocytic activities. When neutrophils are stimulated, silymarin blocks the release of myeloperoxidase. Inoculation of neutrophils with silibin prevents leukocyte motility inhibitors (FMLPs).
Antioxidant properties
Flavonoids such as silymarin (especially silibin) are known to be powerful antioxidants and free radical scavengers. Silymarin also has antioxidant effects on human platelets, and in human liver and lung microsomes, silymarin acts as an antioxidant and free radical scavenger, thus providing protective action against chemical-induced fat peroxidation. Brought. Silymarin also increases the levels of RBC superoxide dismutase and lymphocytes. As a result, it enhances the antioxidant effects.
Treatment of psoriasis
Silymarin is traditionally used to treat psoriasis. The effect of silymarin on the improvement of psoriasis may be due to the excretion of unwanted metabolites from cells of the body, especially the liver, as well as inhibition of the cAMP cycle and inhibition of leukotriene synthesis. In patients with psoriasis, there is an increase in the cAMP cycle and the synthesis of leukotrienes, the inhibition of which may improve the disease.
Uses of Livergel
- Cirrhosis of the liver
- hepatitis
- Fatty Liver
- Constipation
- Anorexia
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