Pharmaceutical class:

Oral hypoglycemic drug

Drug form:

5 mg tablet

Drug combinations:


Mechanism of action of Lirenta

This drug is a specific inhibitor of dipeptidyl peptidase 4 enzyme

Uses of Lirenta

This drug is used along with diet and exercise to lower blood sugar in adults with type 2 diabetes

Use in pregnancy and breastfeeding Lirenta

Pregnancy: Adequate and well-controlled studies have not been conducted in pregnant women. The use of this medicine during pregnancy should be done under the supervision of a specialist and carefully.
Lactation: It is not yet known whether this drug is secreted in human milk, although it is secreted in the milk of rats. Due to the occurrence of unwanted effects in animals, its use during breastfeeding is not recommended.

Regarding the correct way to take the medicine, pay attention to these points:

1- Take this medicine exactly as prescribed by the doctor. Sometimes, the doctor may prescribe linagliptin together with another antidiabetic drug. Remember that in order to achieve the best results, all medications should be taken as directed by your doctor.
2- This medicine can be taken with food or on an empty stomach.
3- In order to achieve the maximum effectiveness of the medicine, take it according to a regular schedule.
4- Continue taking the medicine even if you feel better. Do not forget any of the medication appointments.
5- Before stopping the medicine, consult your doctor. In this situation, the amount of blood sugar may increase.
6- If you forget to take a dose of medicine, take it immediately as soon as you remember. But if it is almost time to take the next dose, take only that dose and avoid doubling the amount of medicine.

Lirenta drug interactions:

Before taking this medicine, inform your doctor if you are using the following medicines:
Angiotensin-converting enzyme inhibitors – linagliptin may increase the side effects or toxic effects of these drugs.
Androgens (except danazol), pegrisomant – the hypoglycemic effect of linagliptin may increase with concomitant use of drugs.
Bosentan, dabrafenib, deferasirox, ciltuximab, tocilizumab – the amount of linagliptin in the blood may decrease with the simultaneous use of drugs.
Corticosteroids (oral inhalation, systemic), danazol, luteinizing hormones, hormone-releasing analogs, somatropin,
Thiazide diuretics – the hypoglycemic effect of linagliptin may be reduced with simultaneous use of drugs.
Ritonavir – the amount of linagliptin in the blood may increase with the simultaneous use of drugs.
Rifamycins (such as rifampin) – the effectiveness of linagliptin may be reduced when taken together.
Insulin, repaglinide, sulfonylurea drugs (such as glipizide) – the possibility of hypoglycemia may increase when these drugs are taken together.
Carbamazepine, phenobarbital, phenytoin, primidone, xcarbazepine – the amount of linagliptin in the blood may decrease with the simultaneous use of drugs.

Precautions Lirenta:

1- Follow the doctor’s instructions regarding diet and exercise. Adhering to a correct diet, regular exercise and regular blood sugar testing play an important role in the optimal effectiveness of this drug.
2- Always carry your ID card that shows you have diabetes.
3- Control the amount of blood sugar according to the doctor’s order. If blood sugar increases or decreases while taking this medicine, consult your doctor.
4- It may be more difficult to control blood sugar levels in stressful situations such as fever, infection, injury or surgery. In such a situation, consult your doctor and avoid changing the amount of medicine without his prescription.
5- Linagliptin usually does not cause low blood sugar, but if taken at the same time as other blood sugar lowering drugs such as insulin and sulfonylureas, it may cause low blood sugar. Symptoms of low blood sugar include anxiety, sweating, weakness, confusion, drowsiness, syncope, rapid heartbeat, vision changes, headache, tremors, and hunger. Taking some fast-acting sugars such as glucose tablets or gels is useful for treating hypoglycemia. If you don’t have access to these substances, eating or drinking quick sources of sugar such as sugar cubes, honey, candy, orange juice or non-diet soda helps. In order to prevent hypoglycemia, eat meals at specific times during the day and do not miss any of the meals.
6- Severe pancreatitis (inflammation of the pancreas) has been reported in some patients using this medicine. If you experience severe or persistent stomach or back pain with or without nausea and vomiting, contact your doctor immediately.
7- While taking this medicine, perform tests related to fasting blood sugar and hemoglobin Alc. These tests are done to monitor the disease or control side effects. Therefore, see a doctor at regular intervals.

Lirenta Contraindications:

1- History of allergy (including anaphylaxis, angioedema, exfoliative dermatitis or skin peeling, urticaria, skin rash, bronchial hyperactivity) to linagliptin or any of the components of this medicine
2- Type 1 diabetes
3- Diabetic ketoacidosis (increased ketones in blood or urine)

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