Ipacin Indications
It is used to treat serious infections caused by gentamicin-resistant gram-negative bacteria. The advantage of this drug over gentamicin in the resistance of this antibiotic against most bacterial enzymes that degrade aminoglycosides.
Ipacin Mechanism of action
By binding to the ribosomal 30S subunit, it inhibits protein synthesis in bacteria sensitive to this antibiotic
Ipacin Pharmacokinetics
Absorption:
Muscular (fast); Oral (low absorption)
Distribution:
Vd: 0.25 L / kg mainly in extracellular fluid (highly hydrophilic); Slight penetration into the blood-brain barrier even in meningitis; Vd is increased in infants and patients with edema, ascites, and fluid overload; Vd is reduced in dehydrated patients
Ipacin prohibited usage
This drug should not be used if the patient has myasthenia gravis
Ipacin Warning
- The interval between doses of the drug in patients with renal impairment should be increased.
- This drug should be used with extreme caution in elderly patients with Parkinson’s disease and neonates.
- Long-term use of this drug should be avoided.
Ipacin Side Effects
Ear cochlear damage, reversible renal toxicity, rarely hypoglycemia, especially in long-term use, and pseudomembranous colitis are possible side effects of this drug.
Ipacin Drug interactions
Concomitant use of aminoglycosides with cephalosporins (especially cephalothin), amphotericin, cyclosporine, and cytotoxic drugs increases the risk of renal toxicity (possibly ear poisoning). Concomitant use of aminoglycosides with vancomycin increases the risk of ear and kidney poisoning. Concomitant use of aminoglycosides with neostigmine and pyridostigmine reduces the effect of these cholinergic drugs. Concomitant use of aminoglycosides with neuromuscular blocking drugs may lead to further skeletal muscle weakness, respiratory failure, and even apnea. The risk of ear poisoning may increase with the use of aminoglycosides with loop diuretics. Concomitant use of two or more aminoglycosides and concomitant use of these drugs with capreomycin should be avoided, as this may increase the risk of ear and kidney poisoning and neuromuscular obstruction. For an overview of the interaction of aminoglycosides with potentially toxic diuretics, see the general monograph of these drugs.
Ipacin Recommended tips
Because the excretion of aminoglycosides is mainly renal and the concentration of these drugs in the urine will be high, the patient should consume enough water or fluids so that the high concentration of the drug does not cause damage to the urinary tract.
It is not recommended to mix this drug with other drugs in a solution because of the possibility of complexing between amikacin and other drugs.
Ipacin Dosage
Adults: 5 mg / kg every 8 hours or 5.7 mg / kg every 12 hours for 7-10 days by intramuscular or infusion or slow intravenous injection.
Children: In premature infants, first 10 mg / kg and then 5.7 mg / kg every 18-24 hours for 7-10 days and infants, 10 mg / kg and 5.7 mg / kg every 12 hours for 7-10 days intramuscular injection or The infusion is given slowly intravenously.
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