Indications: Prevention of cardiovascular events in patients with acute coronary syndrome
Prevention of stent thrombosis in patients undergoing angioplasty
Use in pregnancy and lactation
Medication during pregnancy should be taken under the supervision of a physician and with caution.
Due to the possibility of serious side effects in infants, its use during breastfeeding is done with the advice of your doctor.
Pay attention to these points regarding the correct way of consumption
Take the medicine at a specific time during the day (one morning pill and one evening pill)
The drug can be taken with food or on an empty stomach.
In case of difficulty in swallowing the pill, it can be crushed and consumed with water as follows:
Thoroughly powder the tablet, add it to half a glass of water, stir and drink immediately. In order to ensure that the medicine is fully absorbed, rinse the empty glass with half the volume of water and sip.
Grapefruit juice may increase the antiplatelet effect of this drug.
Avoid abrupt discontinuation of the drug without consulting your doctor. Abrupt discontinuation may increase the chances of another heart attack, stroke, or death related to the heart or blood vessels.
Avoid doubling the dose if you miss a dose. Take the next dose according to your regular schedule.
If you have recently been taking or are taking other medicines, consult your doctor, especially:
Rifampicin, more than 40 mg / day of simvastatin or lovastatin, phenytoin, carbacazpine and phenobarbital, digoxin, cyclosporine, conidine and diltiazem, beta-blockers and verapamil, morphine and other opioids, aspiraxabine, cannabis, apixabrin Carodebolol, Dabrafenib, Dasatinib, Defrazirox, Ibrotinib, Ciatoxime, Tetrahydrocannabinol, Tocilizumbe.
Concomitant use of the following medications may increase the risk of bleeding:
Oral anticoagulants include warfarin
Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used as analgesics (such as ibuprofen and naproxen)
Selective serotonin reuptake inhibitors used as antidepressants (such as paroxetine, sertraline, and citalopram)
Other drugs such as clarithromycin, ketoconazole, nefazodone, ritonavir and atazanavir, cisapride, ergot alkaloids
Fibrinolytic drugs (such as streptokinase or ethylase)
Inform your doctor or dentist before taking any surgery (including dental surgery). Discontinuation of the drug may be necessary for 5 days before surgery.
This medicine may easily cause bleeding, which can be severe or life-threatening. Therefore, avoid activities that may lead to bleeding or injury.
In case of non-stop bleeding, call your doctor or emergency medical center. Bleeding may be inside the body, such as the stomach or intestines. Contact your doctor immediately if you notice black or bloody stools, red or pink urine, cough with blood or vomit, or similar coffee beans.
This medicine usually does not cause any problems while driving and working with machines. If you feel dizzy or have a disturbed level of consciousness, be careful when driving or operating machinery.
Avoid abrupt discontinuation of this medication, even with signs of bleeding, before consulting your doctor. Abrupt discontinuation of this drug may increase the risk of heart attack or stroke.
- History of allergy (including anaphylaxis, angioedema) to ticagrelor or any of its components
- Actively pathological bleeding such as stomach ulcers or intracranial hemorrhage
- History of intracranial hemorrhage
- Severe liver failure
- Concomitant use of ketoconazole, clarithromycin, nefazodone, ritonavir and atazanavir
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