Heparin in the prevention and treatment of deep vein thrombosis and pulmonary thromboembolism, prevention of extracorporeal blood coagulation during cardiac surgery and dialysis, as an adjunct in the treatment of unstable angina, peripheral arterial embolism and reduction of the risk of thrombosis and death in thrombosis Patients with severe and sudden progressive seizures and used as a prophylaxis in orthopedic surgery and general surgery.
Mechanism of action Heparodic
- In regional anesthesia or obstruction of the nerves in the lumbar region, blood dyscrasia, especially low blood platelets, recent delivery, or in cases where neurosurgery or eye surgery is required, pericarditis or leakage of fluid to the pericardium, severe renal failure, Major surgery or wounds that cause large open surfaces Severe damage, especially to the central nervous system, perforation of the spinal cord, ulcers or other active gastrointestinal lesions, ، urinary, respiratory, severe vasculitis, and severe liver failure with caution Be.
- In patients taking heparin, it is recommended to avoid intramuscular injection of other drugs due to the possibility of hematoma and bleeding around the injection site.
- Bleeding from the gums may be a sign of heparin overdose. Heparin treatment increases the risk of local bleeding during and after oral surgery.
- Because heparin is made from animal tissues, it is recommended that in patients with a history of allergies or asthma, a test dose of 1000 units be injected first before starting treatment.
- If you use a treatment program with full amounts of heparin, the dose should be adjusted according to the results of blood coagulation tests for each person.
- Inhibition of aldosterone secretion by heparin can cause high blood potassium. Patients with diabetes mellitus, chronic renal failure, acidosis, high blood potassium, or patients taking potassium-sparing medications are more prone to developing the complication of high blood potassium. In such patients, it is recommended that blood potassium levels be monitored prior to heparin initiation and monitored during heparin administration, especially if heparin administration is to be continued for more than 7 days.
Drug interactions Heparodic
Concomitant use of heparin with valproic acid may cause bleeding due to inhibition of platelet function. Methimazole and propyl thiouracil reduce blood prothrombin. Therefore, concomitant use of these drugs with heparin may increase the anticoagulant effect. Concomitant use of anticoagulants and thrombolytics, such as warfarin, streptokinase, and urokinase, as well as dextran, increases the risk of bleeding. Concomitant use of heparin with probenecid increases and prolongs the anticoagulant effect of the drug. Concomitant use of drugs that affect platelet function (nsaids, dipyridamole, ticlopidine, clopidogrel) with heparin increases the risk of bleeding.
Recommended tips Heparodic
- During treatment with heparin, the use of acetylsalicylic acid or drugs containing it, ibuprofen and other drugs affecting platelets should be avoided.
- The doctor and the dentist should be informed about the use of this medicine.
- In order to evaluate the progress of treatment, regular blood coagulation tests are necessary.
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