Pharmaceutical class:

Combined oral blood sugar lowering drug

Drug form:

5.10 mg tablet and 5.25 mg tablet

Drug combinations:

Empagliflozin + Linagliptin

Mechanism of action of Glorenta

Empagliflozin in the medicine reduces blood sugar by inhibiting glucose reabsorption in the kidney and linagliptin in it by inhibiting dipeptidyl peptidase enzyme.

Uses of Glorenta

Glorenta is used in type 2 diabetes to control blood sugar along with exercise and diet.

Use in pregnancy and breastfeeding

Pregnancy: Not enough studies have been done in pregnant women. For this reason, the use of this drug is not recommended during pregnancy.
Lactation: There is no information available about the secretion of this drug in human milk. However, due to the possibility of serious side effects in infants, its use during breastfeeding is not recommended

Regarding the correct way to take the medicine, pay attention to these points:

1- Take this medicine exactly as prescribed by the doctor. Avoid consuming more or less amounts or for a longer period of time than prescribed by the doctor.
2- Take this medicine once a day in the morning, with food or on an empty stomach.
3- Simultaneous use of this drug with other antidiabetic drugs may be recommended by the doctor. In such a situation, blood sugar can drop.
4- Control your blood sugar according to the doctor’s instructions.
5- When taking this medicine, follow the diet and exercise recommended by the doctor.
6- Consult your doctor about how to prevent, identify and control low blood sugar (hypoglycemia), high blood sugar (hyperglycemia) and complications caused by diabetes.
7- While taking this medicine, sugar may be seen in the urine.
8- If you forget to take a dose of medicine, take it immediately as soon as you remember. But if it is almost time to take the next dose, take only that dose and avoid doubling the amount of medicine.

Glorenta drug interactions

Before taking this medicine, inform your doctor if you are using the following medicines:
Androgens (except danazol), insulin and other hypoglycemic drugs, pegvisomant – the hypoglycemic effect of this drug may be increased.
Corticosteroids (oral inhalation, systemic), danazol, somatropin – the hypoglycemic effect of this drug may be reduced.
Deloxetine, levodopa – This drug may increase the hypotensive effect of diloxetine and levodopa.
Antihypertensives – Antihypertensives may increase the nominal side effects of other antihypertensive medications.
Luteinizing hormones, hormone-releasing analogs, thiazide diuretics – the therapeutic effect of this drug may decrease.
Antihypertensives – Antihypertensives may increase the toxic side effects of other antihypertensive medications.
Luteinizing hormones, hormone-releasing analogs, thiazide diuretics – the therapeutic effect of this drug may decrease. Angiotensin-converting enzyme inhibitors – linagliptin may increase the toxic side effects of these drugs.
Bosentan, dabrafenib, deferasirox, ciltuximab, tocilizumab – the amount of linagliptin in the blood may decrease.
Ritonavir may increase the amount of linagliptin in the blood.
Rifampicin, rifampin – the amount of linagliptin in the blood may decrease.
Carbamazepine, phenobarbital, phenytoin, primidone – the amount of linagliptin in the blood may decrease.

Precautions Glorenta

1- Frequent control of blood sugar and determination of ketones in urine is necessary. This medicine can cause ketoacidosis (too much acid in the blood). Therefore, if the presence of ketones in the urine is positive, even if the blood sugar level is normal, consult your doctor.
2- Hypoglycemia (low blood sugar) may occur in any person with diabetes and its symptoms include headache, hunger, sweating, irritability, confusion, nausea, high heart rate, anxiety, weakness and tremors. To quickly treat hypoglycemia, always have fast-acting sugars with you, such as fruit juice, candy, cookies, raisins, or non-diet soda.
3- Pay attention to the symptoms of hyperglycemia (increased blood sugar such as increased thirst or urination, blurred vision, headache and fatigue.
4- Factors such as stress, illness, surgery, exercise, alcohol consumption or missing meals can affect the amount of blood sugar. Consult your doctor before changing your dosage or medication.
5- This drug can cause the results of some urine sugar tests to become abnormal. Therefore, before doing the tests, inform your doctor about the use of this medicine.
6- While taking this medicine, periodic monitoring of blood sugar, hemoglobin Alc, kidney function (at the beginning and then periodically during treatment), LDL-C, monitoring of fungal infections of the genital tract and urinary tract infections, monitoring of blood pressure, identification and control hypoglycemia and hyperglycemia, evaluate complications caused by diabetes and signs and symptoms of pancreatitis (including severe and persistent abdominal pain that sometimes spreads to the back and may be accompanied or without vomiting).

Contraindications for Glorenta

1- Allergy to empagliflozin, litagliptin or any of the components of this medicine
2- Severe kidney failure, dialysis or end stage kidney disease
3- Type 1 diabetes mellitus, diabetic ketoacidosis
4- Exfoliative dermatitis and history of angioedema

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