Indications Therapeutic effect
One of the most important therapeutic effects is its antibacterial and anti-cancer properties. It also has anti-hypertensive effects, antidote to heavy metal poisoning, modulates the immune system, protects the liver, anti-arthritis, lowers fat and lowers blood sugar
Mechanism of action
Alicom is a medicine made from garlic. Which is in the form of 260 mg Alicom coated tablets containing 100 mg of garlic powder. It is used to lower cholesterol and triglycerides and increase HDL. It also helps prevent atherosclerosis due to its effect on blood pressure and platelet aggregation. On the other hand, it is used to reduce the risk of stroke and heart attack. Allicum is therefore used in hypertension, hyperlipidemia, atherosclerosis and the prevention of thrombosis.
It is taken three times a day, one to two tablets after a meal. Its effective compounds are thioalls and their derivatives such as allyne, allicin, agave, diallyl disulfide and diallyl trisulfide. Studies have shown that garlic has a direct effect on the smooth muscles of the vascular wall, causing vasodilation of peripheral arteries. It seems that this drug causes hyperpolarization of membrane potential and vasodilation of blood vessels by opening potassium channels.
Laboratory studies with aqueous extract, alcoholic extract and garlic powder have also shown that garlic increases nitric oxide production by activating nitric oxide synthetase, thereby lowering blood pressure. These results have also been confirmed by experiments in humans . The effect of garlic on lowering cholesterol and triglycerides may be manifested by inhibition of key enzymes synthesizing cholesterol and fatty acids such as hydroxymethylglutaryl coenzyme A and ethyl coacarboxylase. Garlic prevents clotting by increasing fibrinolytic activity, increasing coagulation and platelet aggregation.
Clinical trials conducted since 1993 on the properties of garlic have shown a reduction in total cholesterol and its effect on reducing platelet aggregation, lowering blood pressure and its antioxidant properties.
Other herbal remedies made from garlic extract include Garlet, Garlic, Garlicap, and Garsin. Garlet is in the form of a 570 mg coated tablet. This pill contains 400 mg of garlic powder and the amount of aline and allicin in each pill is equal to 1000 micrograms. And its active ingredients are similar to allicum. It is taken three times a day, one to two tablets at a time after a meal. Garlic is in the form of 15 ml drops. Each 10 drops of Garlic contains 250 grams of garlic extract. And once to three times a day, 10 drops each time with food or water. Garly Cap is in the form of a 330 mg capsule. This capsule contains 330 mg of garlic powder. Take one to two capsules three times a day with a glass of water after a meal. Garcin is in the form of a 600 mg coated tablet containing 85.42% garlic powder (equivalent to 8.9 mg of allian) .
And three times a day, one tablet is taken after a meal each time. Clinical studies have shown that long-term and regular consumption of garlic powder at a dose of 300 mg per day protects endothelial cells from oxidative damage. Also, consumption of garlic powder in the amount of 800 mg per day for 12 weeks is effective in patients with second degree peripheral artery obstruction. Garlic has strong antimicrobial effects due to the presence of organosulfur compounds (aline, allicin). The most important properties of garlic are related to the alline composition in this plant. Garlic extract plays a role in improving the damage caused by diabetes as well as the protective effects on the kidneys due to its anti-glycosylation and lipid-lowering effects. Other pharmacological effects of garlic include its antioxidant and protective role (garlic has a great effect against high blood pressure, so that a strong inductive role in reducing blood pressure factors (prostaglandin E 2 and thromboxane B 2) It also inhibits the action of the binding enzyme that converts angiotensin I to angiotensin II, and the gamma-glutamyl cysteine in garlic causes this action.
The above shows that the final blood cholesterol of LDL, VLDL and triglycerides is significantly reduced, with the most prophylactic therapeutic effects of garlic in special oils and garlic juice in which sulfur compounds are dissolved, thiosulfates and other metabolites Garlic secondary, including steroids, are responsible for the therapeutic effects of garlic. Research shows that garlic reduces creatinine, which is similar to the effect of gentamicin, so the antioxidant effect of garlic reduces creatinine by blocking calcium channel blockers or increasing vasodilators due to increased nitric oxide. Allicin, which is an oxygenated sulfur compound and the active ingredient in garlic, has been introduced as the main antimicrobial compound in garlic. Allicin has extensive antimicrobial properties on microorganisms. The antimicrobial properties of allicin are due to its chemical reaction with thiol group of many enzymes including Papain, Urease, Succinic, RNA Polymerase, Xanthine oxidase, Cystein and others.
Pharmacokinetics
The main and medicinal compounds of the plant:
The most important medicinal compound in this plant is the amino acid allyn, which is an alkyl derived from cysteine sulfoxide. By crushing, chewing, slicing or extracting garlic, the enzyme allinase in it is released and quickly causes allicin to be lysed and converted to a sulfonic acid called allicin or diallyl thiosulfinate. Garlic contains at least 100 types of sulfur compounds, of which 70 to 80% are allicin. Other important sulfur compounds in garlic are allyl methyl thiosulfonate, apropinyl allyl thiosulfonate and gamma-L-glutamyl-S-alkyl-L-cysteine. Are . Another sulfur compound present in fresh garlic is gamma-glutamyl cysteine, which is converted to aline after hydrolysis and oxidation. S-aline cysteine and S-propyl cysteine have a protective role in acetaminophen-induced hepatotoxicity. Other ingredients in this plant include Scordinine, B, C and D vitamins.
prohibited usage
Alerts:
Caution in this plant: Garlic is not recommended for patients with diabetes, insomnia, pemphigus, organ transplantation and rheumatoid arthritis, as well as in patients after surgery. Excessive consumption of raw garlic increases the risk of adverse reactions. In this case, the patient should be monitored for signs and symptoms of bleeding. In some studies, the use of garlic products in addition to anti-lipid activity, in patients with type 2 diabetes has also led to improved glycemia. However, in diabetic patients who consume garlic may show a further decrease in blood glucose levels. If the patient is taking anti-diabetic medication, he or she should watch for signs and symptoms of hypoglycemia and monitor serum glucose levels. Consumption of garlic is harmful for patients with skin disorders as well as breastfeeding mothers and should be avoided. Because it irritates the baby’s mucosa. Garlic should be used with caution in patients treated with ethyl salicylic acid or other anticoagulants and hypoglycemic drugs. Excessive consumption of garlic may cause bleeding after surgery.
side effects
Consumption of large amounts of garlic or consumption on an empty stomach may cause gastrointestinal disorders such as heartburn, nausea, vomiting and diarrhea. Allergic reactions such as contact dermatitis and asthma attacks with garlic have also been reported in susceptible individuals. This product is contraindicated in people sensitive to garlic and people with acute ulcers of the gastrointestinal tract. Laboratory studies have shown that garlic causes uterine contractions and its safe use during pregnancy and lactation has not been proven. Therefore, it is recommended not to be consumed during this period. Excessive consumption of dried garlic (4 grams per day) causes constipation, vomiting, and gastrointestinal disorders, and consumption of fresh garlic (30 grams) causes severe anemia.
Drug interactions
May increase the effect of anticoagulants
Increases the effect of blood sugar lowering drugs
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