Pharmaceutical class:

The drug of the new generation of oral anticoagulants

Drug form:

2.5 and 5 mg tablets

Drug combinations:


The mechanism of action:

Inhibition of active factor 10 (Xa)

Uses of Elaquit:

  Prevention of stroke in patients with nonvalvular atrial fibrillation (NonValvular Atrial Fibrillation_AF).
Treatment and prevention of re-creation of clots in deep veins (Deep vein thrombosis_DVT) and pulmonary embolism (PE)
Prevention of blood clots after knee joint replacement (Total knee replacement_TKR) and hip (Total hip replacement_THR) surgery.

Use in pregnancy and breastfeeding:

Pregnancy: Adequate and well-controlled studies have not been conducted in pregnant women. It is possible that the risk of bleeding during pregnancy or childbirth will increase in treatment with this drug. Avoid using this medicine during pregnancy and if you become pregnant, talk to your doctor immediately.
Lactation: There is no information available about the secretion of this drug or its metabolites in human milk. Due to the possibility of drug secretion in milk, its use during breastfeeding is not recommended.

Regarding the correct way to take the medicine, pay attention to these points:

1- Take this medicine every day at a specific time according to the doctor’s prescription. The duration of use or discontinuation of the drug should be done by a doctor.
2- Swallow the tablet completely with water. The pill can be taken with food or on an empty stomach.
3- In case of swallowing problems, consult your doctor. The tablet can be crushed and mixed with water, dextrose 5% in water, water or applesauce just before use.
4- If necessary, the doctor may transfer the crushed tablet in 60 ml of water or 5% dextrose in water through the stomach tube.
5- Avoid taking apixaban with grapefruit juice at the same time.
6- Do not stop taking this medicine suddenly without consulting a doctor, because there is a risk of blood clot formation if the treatment is stopped early.
7- According to the doctor’s order, before the medicine package runs out, prepare it again.
8- If you forget to take a dose of medicine, take it immediately as soon as you remember. Then resume your normal schedule. Avoid doubling the amount of medicine. If you forget to take more than one dose, consult your doctor.

Elaquit drug interactions:

Consult your doctor if you have recently used or are currently taking other medications, as well as over-the-counter medications, especially the following:

The simultaneous use of the following drugs may increase the effects of Elacoit and the possibility of unwanted bleeding.
Certain medications for fungal infections (such as ketoconazole, itraconazole)
Certain antiviral drugs for HIV/AIDs (such as ritonavir)
Other medicines used to reduce blood clots (such as enoxaparin)
Non-steroidal anti-inflammatory drugs (such as acetylsalicylic acid or naproxen)
Medicines for high blood pressure or heart disease (such as diltiazem, verapamil)
Antidepressants named specific serotonin reuptake inhibitors or serotonin reuptake inhibitors, norepinephrine, oprepitant, dasatinib, omega-3 fatty acids, and intravenous vitamin E, clarithromycin, erythromycin
The simultaneous use of the following drugs may reduce the effects of Elaquiit in preventing blood clots.
Some drugs to prevent epilepsy with seizures (such as phenytoin, carbamazepine, phenobarbital, primidone)
(tea herb) (herbal supplement for depression)
Medicines used to treat tuberculosis or other infections (rifampicin)
Estrogen derivatives – progestins – envalotamide

Precautions for Elaquit:

Before performing any medical or dental care, medical emergency or surgery, inform your doctor or dentist about the use of this medicine.
If there is a tube (catheter) or intra-spinal injection (to create anesthesia or reduce pain), take this medicine according to the doctor’s order at least 5 hours after the catheter is removed.
If you feel tingling, numbness or muscle weakness, especially in the legs and feet, inform your doctor immediately.
Call your doctor if you fall or are injured, especially if you hit your head.
This medicine contains lactose. In case of intolerance to certain sugars, contact your doctor.
Periodic monitoring and evaluation of patients for signs and symptoms of blood loss such as decreased hemoglobin or hematocrit should be done. During the treatment period, periodical tests of full blood cell count (including platelet count) and tests related to the presence of occult blood in stool are recommended.
Periodic monitoring of patients for signs and symptoms of neurological disorders is recommended.
If needed, renal function should be checked before starting treatment and should be done in all patients at least once a year.
Monitoring of liver function is recommended.

Elaquit Contraindications:

Allergy to apixaban or any of the ingredients of this medicine
– Heavy bleeding
– The presence of a disease in one of the body’s organs that increases the risk of serious bleeding (such as an active or recent gastric or intestinal ulcer, recent cerebral hemorrhage) – Liver disease that leads to an increased risk of bleeding (hepatic coagulation disease)
Taking drugs to prevent blood clots (such as warfarin, rivaroxaban, dabigatran, or heparin), except when anticoagulant therapy is changed or when receiving heparin through an intravenous or arterial line to keep it open.

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