What is Duphaston?

Duphaston tablets contain a drug called dydrogesterone. Diderogesterone is a synthetic hormone that is very similar to the “progesterone” hormone made by the body. Dofaston is used to treat diseases caused by a lack or deficiency of progesterone; Diseases such as menstrual disorders, painful menstruation, premenstrual syndrome (PMS), abnormal uterine bleeding as well as treatment of endometriosis and some infertility cases are controlled by Dofaston. This medicine can be used alone or in combination with estrogen. Another brand name for progesterone pills is Dofamed Pills.

Applications of Duphaston tablets

When the body does not produce enough progesterone and is deficient in progesterone;
To relieve and treat endometriosis (a disorder caused by the growth of endometrial tissue outside the uterus);
To treat infertility due to progesterone deficiency;
To control irregular menstrual cycles;
To relieve the symptoms of premenstrual syndrome (PMS);
To treat amenorrhea and restart menstrual cycles that have stopped before menopause;
To stop or prevent unexpected heavy or prolonged menstrual bleeding (often before the onset of menopause);
Replacing progesterone deficiency in pregnancy to treat spotting or bleeding from pregnancy or to prevent abortions, especially in the first trimester of pregnancy;
Another application of Dofaston 10 mg tablets is the treatment of menopausal symptoms (with hormone replacement therapy or HRT). Dofaston tablets are used alone or in combination with estrogen to treat menopausal symptoms.

How Dufaston works

As mentioned, Dofaston is used to treat problems caused by progesterone deficiency in the body. This hormone is normally produced in the ovaries from puberty to menopause. The synthetic progesterone in dofaston (dydrogesterone) replaces the deficiency of this hormone. In a woman’s body, progesterone is usually balanced against another female hormone called estrogen. Your doctor may prescribe this medicine along with estrogenic drugs to get the proper balance of hormones. Estrogen is an effective drug for treating menopausal complications, but for some postmenopausal women, taking estrogen alone can cause abnormal thickening of the lining of the uterus (endometrium). Taking Dofaston tablets as part of the menstrual cycle prevents the lining of the uterus from thickening.

Contraindications Dofaston

• In the presence of tumors that are exacerbated by progestogens (such as meningiomas);
• If you have irregular or abnormal, heavy periods that have no known cause, in which case the cause of the bleeding must be determined before you start taking this medicine;
• Sensitivity to any of the ingredients of Dofaston;
• In case of depression;
• Having liver problems;
• If you have a rare inherited blood problem called porphyria.

Notes when consuming

How to take Dofaston tablets is as follows:
Do not worry if you experience unexpected vaginal bleeding or spotting from taking Dofaston 10 mg tablets. This is normal in the first few months of taking this medicine. However, if you have frequent bleeding or cause you anxiety, consult your doctor. But if the spotting has persisted even after stopping treatment or for more than a few months, you must see a doctor.
You may feel a little drowsy or dizzy after taking Dofaston tablets, which is more likely to occur within the first few hours after taking it. If you feel drowsy, avoid driving and using sharp and dangerous objects until this feeling disappears.
Dofaston contains lactose (milk sugar). If you have a history of lactose intolerance or are unable to digest it, consult your doctor before taking this medicine.
Duphaston tablets are not recommended for children and adolescents before puberty because the safety and efficacy of this drug are not yet known in young people aged 12 to 18 years.
Dofaston tablets can be used for HRT (hormone therapy) in older people (over 65).
If Dofaston is overused (even by children), the risk of harm is very low and no special treatment is needed. But you may experience nausea, drowsiness, dizziness, or vomiting, which you can talk to your doctor about if you are worried.
• If you forget to take your pill in one day and less than 12 hours after taking it, take it and take the next pill in normal time. If more than 12 hours have passed since you should have taken your pill, do not take the missed pill and take the next pill at the usual time, and do not take a double dose to make up for a forgotten dose. If you forget to take the pill at one meal, you may have spotting or irregular bleeding. Be sure to tell your doctor before stopping Dofaston.

The effect of Dofaston pill on pregnancy and lactation

The effect of Dofaston on fertility:

Does Duphaston cause pregnancy? There is no evidence of decreased fertility due to the use of dydrogesterone (found in Duphaston pills), but even in cases such as treatment of menstrual irregularities in polycystic ovary disease, treatment of progesterone deficiency in preventing recurrent miscarriages and improvement of luteal phase in treatments. Infertility may improve fertility in infertile women.

The effect of Dofaston on pregnancy:

To date, there has been no evidence that dydrogesterone is harmful during pregnancy. Studies have shown that children whose mothers used synthetic progesterone during pregnancy may be at risk for hypospadias (congenital defects in the penis of boys involving the opening of the urethra below normal) in children. That their mothers used synthetic progesterone during pregnancy. However, as there are many other factors that can cause this problem during pregnancy, there is no definitive conclusion about the role of dydrogesterone in the development of hypospadias. Clinical studies in a limited number of pregnant women treated with dydrogesterone in the first trimester of pregnancy showed no increased risk. No other epidemiological information is available so far. Even the manufacturer of this drug has suggested its use to treat cases of threatened abortion and to prevent abortion (recurrent miscarriage). Harmful effects of this drug have been seen only if taken in excess of the maximum allowable amount in pregnancy. As a result, dydrogesterone can be used during pregnancy if prescribed correctly by a doctor. If you become pregnant or think you may be pregnant, talk to your doctor about the side effects and benefits of Dofaston.

The effect of Dofaston on breastfeeding:

Avoid dofaston if your baby is breast-feeding. There is no definite information about the transfer of Dofaston to breast milk and its effect on the baby, but studies on other progesterones show that small amounts are transferred to breast milk.

How to take Dofaston

How to take Dofaston 10 mg tablets should be exactly as your doctor advised, and you should consult your doctor or pharmacist if you are unsure about how to take it. The dose of Dofaston will be prescribed by your doctor depending on your problem. If you are taking Dofaston tablets, you should see your doctor regularly (at least once a year). Your doctor may want to perform medical tests, including breast tests and Pap smears.
Other notable things about how to take Dofaston include the need to take tablets with water. You can take Dofaston tablets with or without food. If you have to take more than one pill during the day, distribute them evenly; for example, if you are prescribed two pills a day, take one pill in the morning and one pill in the evening. Try to take your pill at the same time every day. This will ensure that there is always a constant amount of medicine in your body. It also prevents you from forgetting to take your pills. The center line on each pill is just to help break the pill, and this should not be taken to mean that half the pill should be used.

Side effects of Duphaston

Dofaston, like all medicines, may have side effects, although not everybody gets them. Here are some side effects of Dofamed 10 tablets.
The most common side effects of Dofaston tablets (less than 1 in 10 people):
Mild pain in one or both breasts;
Painful, heavy, and irregular periods are associated with the effects of Duphaston and menstruation;
Menopause or menstrual bleeding less than usual.

Uncommon side effects of Dofaston tablets (less than 1 in 100 people):

Weight Gain;
Rash, severe itching or hives;
Feeling depressed;
Feeling dizzy;

Rare side effects of Dofaston tablets (less than 1 in 1,000 people):

Low levels of red blood cells (hemolytic anemia);
Sensitivity reactions;
Fluid retention (ie, the body retains more water than usual);
Breast swelling;
feeling sleepy;
Increase in the size of progesterone-affected tumors (such as meningiomas).

If you notice any of the following severe symptoms, stop taking Dofaston and see a doctor immediately as you may need immediate medical treatment:

Allergic reactions, which may be another side effect of Dofaston tablets, can be difficult to breathe or more general reactions such as feeling sick, the onset of illness, diarrhea or low blood pressure;
Swelling of the skin around the face and throat that may cause difficulty breathing (angioedema);
Liver problems: Symptoms may include yellowing of the skin or eyes (jaundice), general tiredness with abdominal pain, or other liver-related changes.




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