Indications Dopadic
Dopamine is used to treat cardiogenic shock from stroke or heart surgery. In septic shock, small amounts of dopamine may be given in combination with norepinephrine to maintain renal blood flow.
Mechanism of action Dopadic
- It exerts its positive inotropic effect by stimulating beta-adrenergic receptors in the heart muscle.
- Dopamine stimulates postsynaptic dopamine receptors in smooth muscle and kidney arteries, dilates arteries and increases sodium excretion.
- In addition, it stimulates blood vessels by stimulating both alpha one and two receptors.
Pharmacokinetics Dopadic
- Dopamine is rapidly distributed throughout the body after intravenous administration and is converted to inactive metabolites in the liver, kidneys, and plasma by monoamine oxidase and catechol methyltransferase.
- The plasma half-life and drug elimination are 2 and 9 minutes, respectively.
- There are individual differences in dopamine clearance, which is partly due to abnormal function of organs such as the liver or kidneys (which reduces dopamine clearance). 80% of the drug is excreted by the kidneys in the form of metabolites during the first 24 hours.
prohibited usage Dopadic
It should not be used in cases of tachyarrhythmia and pheochromocytoma
Warning Dopadic
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- Prior to dopamine administration to patients with shock or myocardial infarction, some blood volume should be corrected.
- Dopamine should not be prescribed to patients receiving monoamine oxidase inhibitors. If necessary, the drug should be prescribed as little as possible.
- In the shock of a heart attack, low levels (less than 5 micrograms per minute) of dopamine should be used, as higher doses can worsen heart failure by constricting blood vessels.
- During intravenous dopamine infusion, necrosis occurs if large amounts of dopamine leak into surrounding tissues.
side effects Dopadic
Complications such as nausea, vomiting, peripheral vascular stenosis, hypotension, hypertension, increased heart rate, angina and arrhythmia, and rarely polyuria have been reported with this drug.
Drug interactions Dopadic
Concomitant use of this drug with antidepressant drugs that inhibit the enzyme monoamine oxide may cause severe hypertension.
Recommended tips Dopadic
- Dopamine leakage into the tissues around the vessel can be successfully treated by topical injection of phentolamine up to 12 hours after leakage.</li?
- In case of side effects of dopamine, due to the short half-life of this drug, these side effects are eliminated quickly by slowing down the infusion or stopping it.
- The drug should be diluted before injection.
Dosage Dopadic
Intravenous infusion is initially consumed up to 2-5 mcg / kg / min.
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