Pharmaceutical grade:
Calcium effect mimics (Calcimimetic)
Drug form:
30 mg, 60 mg and 90 mg tablets
Drug combinations:
Synaclast
Diparon mechanism of action:
This drug reduces the release of parathyroid hormone by increasing the sensitivity of calcium receptors on the parathyroid gland regarding extracellular calcium.
Diparon uses:
This drug is used to treat severe high blood calcium levels (Hypercalcemia) in patients with primary hyperparathyroidism who are unable to undergo surgery to remove the parathyroid gland, and for the treatment of secondary hyperparathyroidism in dialysis patients with chronic kidney disease; This drug is also used to treat severe high blood calcium levels (Hypercalcemia) in patients with parathyroid gland cancer.
Diparon drug interactions:
Before taking this medicine, inform your doctor if you are using the following medicines:
Amitriptyline, desipramine, nortriptyline, clomipramine – when used simultaneously with this drug, the amount of amitriptyline and nortriptyline (active metabolite) and other drugs in the blood may increase in some patients.
Carvedilol, flecainide, metoprolol, thioridazine, most of the tricyclic antidepressants, vinblastine – in combined use, adjusting the dosage of these drugs may be necessary.
Erythromycin, itraconazole, ketoconazole, voriconazole, telithromycin, rifampicin, ciprofloxacin, ritonavir, fluvoxamine – when used together, the amount of cinaclost in the blood may increase.
In the simultaneous use of ketoconazole and cinaclost, it may be necessary to adjust the dosage of cinaclost and the level of calcium in the blood must be carefully monitored.
Diparon precautions:
1- In order to check the effectiveness of this medicine, visit your doctor at regular intervals.
2- Do not take other medicines at the same time without consulting your doctor. The doctor may change the dosage of Diparone or other drugs during simultaneous use.
3- This drug may reduce the amount of calcium in the blood. Symptoms caused by low calcium in the blood, abdominal contractions; disturbance of consciousness; convulsive attacks; difficulty in breathing; irregular heartbeat; Mood or mental changes; muscle contractions in the hands, arms, legs, or face; numbness and tingling around the mouth, fingertips or feet; It includes shortness of breath and tremors. If you see any of these symptoms, contact your doctor immediately.
4- This drug may increase the probability of convulsive attacks in patients with a history of convulsive attacks.
Diparon contraindications:
1- History of allergic reaction to cinaclost or any of the components of this medicine
2- Hypocalcemia (decrease in blood calcium to a normal level)
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