Common name:
Диклофенак (Tajik)
ไดโคลฟีแนค(Thai)
Diclofenaco(spanish)
디클로페낙(Korean)
Diclofénac (French)
Диклофенак (russian)
ഡിക്ലോഫെനാക്(Malayalam)
What is Diclofenac?
There is a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) that have analgesic and anti-inflammatory effects and do not contain corticosteroids.
Anti-inflammatory pain relievers such as diclofenac, known as NSAIDs, are used to relieve pain such as arthritis, muscle spasms or bone injuries, gout, migraines, toothaches and postoperative pain. have. Anti-inflammatory pain relievers such as diclofenac, known as NSAIDs, are used to relieve pain such as arthritis, muscle spasms or bone injuries, gout, migraines, toothaches and postoperative pain. have.
This medicine helps to improve the patient’s condition by reducing inflammation and relieving pain.
By blocking the effect of cyclooxygenase, diclofenac reduces the production of a chemical called prostaglandin in the body, which is responsible for causing pain and inflammation in the affected area. Inflammation is reduced.
This drug is a very good analgesic and helps to improve the patient’s condition by reducing inflammation and relieving pain .By blocking the effect of cyclooxygenase, diclofenac reduces the production of a chemical called prostaglandin in the body, which is responsible for causing pain and inflammation in the affected area. Inflammation is reduced.
Diclofenac is produced in two forms: diclofenac sodium and diclofenac potassium.
The main difference between the two is that diclofenac potassium is absorbed faster in the body, so diclofenac potassium is a better choice with a faster effect on acute and sudden pain that requires immediate pain relief.
Diclofenac is not recommended for people with cardiovascular disease or a history of heart attack or stroke because it somewhat increases the risk of heart attack and stroke in susceptible individuals. If you have a history of heart disease, be sure to talk to your doctor or pharmacist about the right painkiller.
It is also available as oral tablets, topical gels, skin patches, eye drops, and injections.
Before taking Diclofenac
Tell your doctor if you have a history of allergies to any medication (especially painkillers, aspirin, etc.).
Tell your doctor if you have a history of stomach or duodenal ulcers, gastrointestinal bleeding, asthma, liver and kidney problems, a recent illness that has caused diarrhea and dehydration, and more.
Diclofenac injection is not recommended for children under 12 years of age.
Diclofenac is not recommended for people with cardiovascular disease or a history of heart attack or stroke because it somewhat increases the risk of heart attack and stroke in susceptible individuals. If you have a history of heart disease, be sure to talk to your doctor or pharmacist about the right painkiller.
Tell your doctor if you are pregnant or breastfeeding.
-Because this drug can interfere with the function of other drugs in the body, it is necessary to give a list of all your drugs to your doctor or pharmacist before starting to take (especially digoxin, lithium, antibiotics (such as ciprofloxacin), Cyclosporine, methotrexate, clopidogrel, antihypertensive drugs, anti-diabetic, steroids (betamethasone, dexamethasone, etc.), phenytoin and other analgesics)
The use of this drug in pregnant women is allowed only with the advice of a doctor. However, injection of this drug in the last 3 months of pregnancy can have renal and vascular complications for the fetus.
The correct way to take Diclofenac
case of long-term use, ask your doctor about the amount and number of times a day. Depending on the situation, you may need 1 to several tablets a day.
It is better to take diclofenac with a glass of milk or after a meal to reduce gastrointestinal side effects.
Today, different types of diclofenac oral tablets are made and available in the pharmaceutical market. Usually, the type of preparation and coating of the pill are different. Read because some pills (such as tablets with an opening in the gut) should not be halved or chewed.
If you miss a dose, skip the missed dose and take the next dose as scheduled. By no means do I want to convey that I recommend for the mother to be inactive.
Recommendations about Diclofenac
Your doctor may prescribe diclofenac in small doses at the beginning of the day to reduce the risk of gastrointestinal side effects. Prescribe to reduce complications.
In case of long-term use, stay under the supervision of your doctor to perform the necessary periodic tests and examinations.
If you have asthma, symptoms such as wheezing and difficulty breathing may be exacerbated by taking this medicine. If these side effects occur, stop taking this medicine and see your doctor.
Tell your doctor if you plan to have surgery or dental treatment.
Common side effects of Diclofenac
Gastrointestinal symptoms such as indigestion, heartburn, stomach pain, etc. are common symptoms of NSAIDs, which are recommended to be taken after meals. If these side effects persist, consult your doctor.
The feeling of nausea caused by this drug is reduced by consuming light meals and avoiding high-fat and spicy foods.
See your doctor if you have breathing problems, or any symptoms of drug allergies (such as swelling of the face and mouth).
If you notice blood or dark stools, vomiting containing blood or severe abdominal pain, stop taking the medicine and see your doctor.
Injection:
Other complications (percentage unknown):
Cardiovascular: edema, cerebrovascular accidents, hypertension, myocardial infarction, cardiovascular events index
Central nervous system: headache, dizziness
Skin: itching, skin rash, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrosis
Endocrinology and metabolism: Water retention
Gastrointestinal: constipation, abdominal pain, diarrhea, indigestion, esophageal perforation, bloating, gastrointestinal ulcers (including stomach / duodenum), heartburn, intestinal perforation, nausea, vomiting
Hematology and oncology: anemia, bleeding, prolonged bleeding time
Hepatic: increase in liver enzymes, increase in serum levels of transaminases, increase in serum alanine aminotransferase, increase in serum aspartate aminotransferase
Hypersensitivity: Anaphylactic-like reaction
Topical: infusion site reaction, drug leakage
Ear: tinnitus
Renal: Kidney insufficiency
Miscellaneous: Impaired wound healing, gastrointestinal inflammation
Diclofenac ampoule
The injectable form of this drug is used in cases such as severe pain due to kidney stones, bone pain, rheumatism and joint pain, low back pain, gout and pain due to bone fractures in children over 12 years and adults.
Injection of this drug should be done only with a doctor’s prescription and in a medical center. How to inject this drug can be inside the patient’s muscle, depending on the condition.
Diclofenac suppository
Diclofenac 100 mg suppository is as effective as an ampoule in adults and is one of the most potent non-narcotic analgesics. The effect of fever on diclofenac 50 and 100 suppositories is also very significant in children and adults and is prescribed by a doctor when necessary.
Long-term use of diclofenac reduces its analgesic effect and increases the risk of side effects. Gastrointestinal ulcers and allergy symptoms are the most important side effects of this drug
Mechanism of action of Diclofenac
Diclofenac is a potent inhibitor of cyclooxygenase. It also reduces prostaglandins, prostacyclin and thromboxane.
Pharmacokinetics of Diclofenac
Diclofenac is completely absorbed orally or rectally. The maximum serum concentration occurs 2 hours after oral administration. The protein binding of the drug is 99% and the drug metabolites are inactive and its half-life is 2 hours. The drug is mainly excreted in the urine
Contraindications to the use of Diclofenac
This drug is strictly forbidden in the third trimester of pregnancy and is classified as a group X drug* and may cause fetal death or organ failure.
It should not be used in patients sensitive to ASA or other NSAIDs and in patients with hepatic porphyria.
group X drug: (Conditions will be completely different during pregnancy! Because everything you receive as a mother reaches the fetus and can affect her health. For this reason, before taking medications, you should make sure that they are safe during pregnancy)
Warnings Diclofenac
Important: It is forbidden to take this medicine before and after coronary artery bypass graft surgery
1. It should be used with caution and with the least possible amount in patients with renal, hepatic or cardiac disorders. In addition, the condition of kidney function should be checked regularly.
2. Do not use in patients with active gastric ulcer. Also, patients with a history of ulcers should avoid this drug and stop taking it in case of gastrointestinal injuries.
3. This drug should be used with caution in the elderly as well as people with a history of asthma and allergies.
Category X Interactions (Avoidance):
Ashemetasine, Aminoluvinolic acid (systemic), Deferiprone, Dex ibuprofen, Dex ketoprofen, Fluctafenine, Ketorolac (nasal, systemic), Massimurlin, Mifamortide, Morniflumate, Tolobate, O-selective nonsteroidal anti-inflammatory drugs (CO) Tenoxicam, urokinase, zaltoprofen
Reducing the effects of drugs by diclofenac
Aliskiren, Angiotensin II receptor blockers, Angiotensin converting enzyme inhibitors, beta-blockers, Eplerenone, Hydralazine, Loop diuretics, Massimorlin, Mifamortid, Potassium-sparing diuretics, Seroconate selectors, Prostaglandin Thiazide and quasi-thiazide
Increased effects of drugs by Diclofenac
5-Aminosalicylic acid derivatives, antiplatelet drugs, aliskiren, aminoglycosides, aminolucinic acid (systemic, topical), anticoagulants, apixaban, artesonate, bimparin, bisphosphonate derivatives, cispecene sycophenate, cispecemone, cispecinate Ethoxylate, defrasirox, deoxycholic acid, desmopressin, dex ibuprofen, digoxin, drospirenone, adoxaban, enoxaparin, apleronone, haloperidol, heparin, iberitomum thiocestane, non-selective drug, lithium methopharynx, methimethine, metformin ), Obinotosumbe, omastaxin, porphyry, potassium-sparing diuretics, paralaterexate, quinolones, rivaroxaban, salicylates, tacrolimus (systemic), tenofovir products, thrombolytic drugs, anorectin, tolpericone, tolperisone
Increased effects of Diclofenac by drugs:
Acalabrotinib, Acesomethacin, Alcohol (ethyl), Angiotensin-converting enzyme inhibitors, Angiotensin II receptor blockers, Corticosteroids (systemic), Cyclosporine (systemic), Oil-based inhibitors of fenugreek, C-2 , Fluctafenine, glucosamine, herbs (with anticoagulant / antiplatelet properties), ibrotinib, inotersen, ketorolac (nasal, systemic), limaprost, loop diuretics, lomacafter and ivacaphthor, morniflumate, multivitamin / ha / E), multivitamin / mineral (containing vitamins A, D, E, ka folate, iron), multivitamin / mineral (containing vitamins A, E, free of iron), naphthazone, omega-3 fatty acids, plubiprofen, pentosan sodium sulfate , Pentoxifylline, Phenylbutazone, Probenecid, Prostacyclin analogues, Resveratrol, Selective serotonin reuptake inhibitors, Salometinib, Serotonin / norepinephrine reuptake inhibitors, Sodium phosphate, Taleniflumate, Tolipidazine, Tenoxibirum thiopericamide Three rings (amine type Third), Vitamin E (systemic), Vericonazole, Zaltoprofen, Zanobrotinib
Food interference:
has not been stated.
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