Atropine is prescribed as a paralytic for the ciliary body to measure refractive errors, treat inflammation of the iris, cilia, and choroid, and dilate the pupil.
Atropine in the treatment of spasmodic pylorus, gastrointestinal spasm, with morphine in the treatment of biliary spasmodic disorders, in renal colic, in the treatment of painful menstruation and enuresis, to reduce intestinal muscle tone during imaging, to reduce salivation and discharge Respiratory anesthesia to prevent bradycardia and sinus cessation and low blood pressure induced by succinylcholine, as an antidote to the treatment of intoxicants with cholinesterase inhibitors, including gano phosphorus toxins’ with neo-stigmine or pyrid-stigmine It is used to relieve the effects of neuromuscular blockers and in Parkinson’s disease.
Elderly patients are more sensitive to atropine and are more likely to have systemic reactions.
It should be prescribed with great caution in patients with primary glaucoma or in patients with a history of closed-angle glaucoma.
Infants and children are more susceptible to the toxic effects of atropine. Paradoxical reactions may be observed in these patients at high doses.
Due to the decrease in sweat, the body temperature rises.
There is a possibility of excitement and irritability in the elderly with values in Mani. There is also the possibility of memory impairment in these patients.
Use with caution in cardiac arrhythmia, lack of gastrointestinal tenus, urinary retention, enlarged prostate, ulcerative colitis, pregnancy and lactation, and glaucoma.
side effects Dicatro
- Elderly patients are more sensitive to atropine and are more likely to have systemic reactions.
- It should be prescribed with great caution in patients with primary glaucoma or in patients with a history of closed-angle glaucoma.
- Common side effects of this drug include constipation, dry mouth, nose, throat or skin, and difficulty swallowing, male macular opening, double nose, bradycardia, and then tachycardia, and decreased sweating.
Atropine may interfere with the anti-glaucoma effect of pilocarpine. This drug can counteract the diuretic effect of atropine. Concomitant use of atropine with ocular’s cholinesterase inhibitors may counteract the anti-glaucoma and pupil narrowing effects of these drugs.
Concomitant use of this drug with glucocorticoids and haloperidol can increase intraocular pressure. If antihistamines and other anti-muscarinic drugs, diso pyramid, phenothiazines and tricyclic antidepressants are used concomitantly, the anti-muscarinic effects may be exacerbated. When used concomitantly with anti-myasthenic drugs, it reduces intestinal motility as much as possible.
Recommended tips Dicatro
- This medicine may cause blurred vision or photosensitivity.
- To prevent systemic absorption, press the tear duct (inner corner of the eye) with your finger while taking atropine drops and for 1-2 minutes afterwards.
Mechanism of action
It inhibits the effect of acetylcholine on saccharin hair receptors and can therefore affect smooth muscle, myocardial reticulum receptors, sinus and atrial and atrial-ventricular nodes, exocrine glands, gastrointestinal motility, and tenus. Tracheal table and bladder effect is used as an antidote. The anti-dizziness effect of true dizziness and Parkinson’s disease is due to the same effect on the brain. In general, low levels of atropine inhibit salivation, bronchial secretions, and perspiration, while drug accumulation dilates pupils and increases heart rate. Pharmacokinetics of atropine
Atropine is even absorbed from the gastrointestinal tract and is enzymatically metabolized in the liver. The drug spreads throughout the body and easily crosses the blood-brain barrier. The duration of its effect is very short and 50-50% of the drug is excreted through the kidneys. The elimination half-life of Atropine from the body is 2.5 hours.
It should not be used in closed-angle glaucoma
- Do not go to hot environments or engage in strenuous physical activity after taking the drug.
- There may be visual disturbances or photosensitivity.
- There is a possibility of dry mouth, nose or throat.
- Intravenous injection of atropine should be done slowly.
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