What is Demetron?

1. Demetron or ondansetron is prescribed to prevent nausea and vomiting after surgery, chemotherapy and radiotherapy.
2. Demetron tablets should be dissolved on the tongue. This pill should not be chewed or swallowed.
3. This medicine is not used to treat nausea of pregnancy or travel.


This drug is used to treat and prevent nausea and vomiting before surgery, chemotherapy, radiation therapy and cancer treatments in general. Demetron tablets cannot be used to treat nausea in conditions other than those mentioned.

This drug is prescribed in the early stages and continuous repetition of chemotherapy to prevent nausea and vomiting. Also, in radiotherapy where radiation is applied to the whole body or the abdomen is irradiated daily, ondansetron tablets or ampoules should be prescribed to prevent nausea and vomiting.

It is not recommended to use this medicine in surgeries where the probability of nausea and vomiting is low. But if there is a high possibility of nausea and vomiting or if this complication should be avoided after the operation, Demetron is prescribed.

Mechanism of action

This medicine is prescribed to control nausea and vomiting. This antiemetic action is done through the selective inhibition of the serotonin receptor. This drug has more relevant and better activity than other anti-nausea drugs.

Pharmaceutical forms

Demetron medicine is available in the following three forms. According to the patient’s needs, the doctor can prescribe any of these forms of medicine. The medicine should be taken only according to the doctor’s instructions.

Demetron tablet
Demetron syrup
Demetron ampoule

consumption instruction

As we said, this medicine is produced in three forms. Before taking Demetron tablets, syrup or ampoules, you should read the instructions carefully and ask your doctor about how to use them. Do not change the dosage without consulting your doctor.

Ondansetron tablets should not be swallowed or chewed like other tablets. This tablet should dissolve on the tongue. You must dry your hands completely before taking Demetron tablets. Open the foil of the tablet slowly and place the tablet on the tongue. After a few seconds it dissolves and you can swallow it with saliva. After swallowing the dissolved tablet, there is no need to drink water or other liquids. Drinking water after taking pills increases the possibility of headache.

Ondansetron can be taken with or without food. But your doctor will probably advise you not to eat before surgery, chemotherapy or radiation therapy.

1. How to take ondansetron to prevent chemotherapy nausea

The timing of medication is very important in preventing nausea. If this drug is prescribed to prevent nausea from chemotherapy, you should take it about 30 minutes before the treatment to have an effect.

The next doses of the drug should be determined by the doctor. It is possible that the doctor will recommend you to use Demetron tablets 3 times a day for 1 or 2 days after chemotherapy.

2. How to take ondansetron for radiotherapy

If your doctor has prescribed this medicine to prevent nausea from radiotherapy, try to take Demetron 1 to 2 hours before the start of treatment. Using this pill can be effective in whole body or abdominal radiotherapy.

After radiation therapy, the doctor may recommend taking the medicine for a short time. Usually, the use of ondansetron tablets should be continued for 1 or 2 days after radiation therapy. This pill should be taken 3 times a day.

3. How to take Demetron tablets for vomiting after surgery

Demetron tablets or ampoules are used to prevent nausea and vomiting after surgery. For a better effect, the drug should be taken about 1 hour before surgery.

Demetron dosage

The dose of this drug is determined based on the age and weight of the patient and the reason for prescribing the drug. In this case, be sure to pay attention to the doctor’s instructions and do not reduce or increase the dose of the drug without consulting a specialist.

Prevention of moderate nausea and vomiting after chemotherapy:

Adults and children over 12 years of age should take 2 Demetron 4 tablets 30 minutes before treatment to prevent nausea and vomiting during cancer treatment. 8 hours after taking the first pill, 2 Demetron 4 pills should be taken again. This instruction should be repeated every 12 hours for two days.

Children from 4 to 11 years old should use one Demetron 4 tablet 30 minutes before treatment. Demetron 4 tablets should be taken again 4 and 8 hours after the first dose. The child should take one pill every 8 hours for 2 days. For children under 4 years old, the dose of medicine should be determined by the doctor.

Prevention of severe nausea and vomiting after chemotherapy:

Adults and children over 12 years of age should take 6 Demetron 4 tablets 30 minutes before chemotherapy. In children under 12 years old, the dose of medicine should be determined by the doctor.

Prevention of nausea and vomiting after radiation therapy:

Adults should take 2 Demetron 4 tablets 1 to 2 hours before radiation therapy. After that, 2 tablets should be used every 8 hours. The use of medicine for children should be determined by a doctor.

Prevention of nausea and vomiting after surgery:

Adults should take 4 Demetron 4 tablets one hour before anesthesia. The dosage of the drug for children should be determined by the doctor.

side effects

This medicine may cause side effects. Some complications are common and some are rare. In case of serious side effects, be sure to contact your doctor. You can consult with a gastroenterologist or drug consultation with a pharmacist through your doctor’s website. In addition to the face-to-face appointment system, Doktorto also offers online and telephone consultations.

Common side effects

Fast heartbeat
Difficulty breathing

Less common side effects:

Decreased frequency of urination
Decreased urine volume
Difficulty urinating
Painful urination

Rare complications

Arm, back and jaw pain
Chest pain, discomfort, tightness, or heaviness
Decreased urination
Difficulty breathing
Difficulty swallowing
dry mouth
Fast or irregular heartbeat
increased thirst
loss of appetite
Loss of bladder control
Mood changes
Loss of consciousness
Muscle pain or cramps
Nausea or vomiting
Loud breathing
Numbness or tingling in the hands and feet
Puffiness and swelling of eyelids, face, lips and tongue
Skin rash, hives and itching
Unusual tiredness or weakness.

prohibited usage

You should tell your doctor if any of the following apply to you. It is possible that the doctor will substitute another medicine.

Patients with serotonin syndrome should not use ondansetron tablets. If you experience anxiety, restlessness, rapid heartbeat, fever, sweating, nausea or diarrhea after taking the medicine, call your doctor immediately.
This drug increases serotonin in the body. For this reason, people with serotonin syndrome or patients who use serotonin-enhancing drugs should not take this drug.
Ondansetron may harm the fetus during pregnancy. This medicine can be used during pregnancy only in emergency situations.
If you are allergic to ondansetron or similar medicines.

Drug interactions

This medicine may interact with some other medicines. Taking them at the same time can change the performance of any of the drugs or aggravate their side effects. Before taking ondansetron, you must provide your doctor with complete information about your medical history and the medications you are taking.

Medicines that interact with Demetron include

Procaine amide
Macrolide antibiotics such as erythromycin

Precautions for use

If your nausea and vomiting does not decrease after taking the medicine, consult a specialist. Before taking the medicine, pay attention to the following points.

Do not use this medicine at the same time as apomorphine. Because they increase the risk of serious problems.
Endonesterone can cause serious allergic reactions such as anaphylaxis. If you notice symptoms such as rash, itching, hoarseness, difficulty breathing, and swelling of hands and face while using the medicine, call your doctor.
This drug can cause a heart problem called myocardial ischemia. In this condition, blood supply to the heart decreases. Watch out for symptoms such as chest pain and discomfort, nausea, arm, jaw, back and neck pain, sweating and breathing problems.
If you have a history of heart disease, liver problems, and stomach and intestinal diseases, be sure to inform your doctor.

Demetron medicine in pregnancy

Ondansetron tablets are prescribed during pregnancy only when necessary. Because there is a possibility that the medicine will harm the fetus. For this reason, you should consult your doctor about the advantages and disadvantages of taking the drug during this period.

Demetron medicine in breastfeeding

In relation to the transfer of Demetron drug through breast milk to the baby, not enough research has been done. For this reason, it is not known whether ondansetron harms a nursing baby or not.

If you take too much of this medicine, call emergency care immediately. An overdose of ondansetron can cause the following symptoms.

Sudden loss of vision
severe constipation
Feeling lightheaded

What to do if you forget to take Demetron?

If you forget to take a dose of medicine, use it as soon as possible. But if it is close to the time of the next turn, you should ignore the missed turn. Do not double the dose. If you experience nausea and vomiting after forgetting to take the medicine, take the medicine immediately. This instruction applies to Demetron tablets, ampoules and syrup.

Demetron tablets for children

Demetron tablets or syrup may also be prescribed for children. If the child needs chemotherapy, radiation therapy or surgery, the doctor can prescribe this medicine. The dose of medicine for children should be determined according to their age and weight. For this reason, only a specialist can determine the dosage of medicine for children.

Demetron anti-vomiting pill

This pill is known as an anti-vomiting pill. But you should note that this medicine cannot be used to prevent any kind of nausea and vomiting. For example, this pill cannot be used to treat nausea during pregnancy or motion sickness.

Demetron tablets and constipation

Ondansetron tablets can cause constipation and intestinal problems in some people. Constipation is one of the common side effects of this drug. But if the constipation was continuous or accompanied by stomach and intestinal pain, you should inform the doctor.

Demetrion and gastritis

One of the rare side effects of ondansetron is stomach inflammation. If you have stomach upset, be sure to inform your doctor.

Demetrion and stomach ache

Usually, this medicine does not cause serious and worrying side effects. But if you have stomach pain after taking the medicine, be sure to inform your doctor about this. This medicine may cause swelling in the stomach area and cause serious stomach or intestinal problems.

Demetron in patients with liver problems

This drug can cause complications for people with liver problems. If you have liver disease, be sure to tell your doctor. Patients with liver failure should not take more than two tablets of Demetron 4 per day.

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