Pharmaceutical grade:


Drug form:

10 mg tablet

Drug combinations:


The mechanism of action:

This drug works as benzodiazepine receptor agonists and facilitates the entry or increase of GABA action and increases the entry of chlorine ions into cells.

Uses of clobium:


Use in pregnancy and breastfeeding:

Pregnancy: The use of this medicine in the first trimester of pregnancy may increase the possibility of birth defects. Also, the continuous use of the drug during pregnancy may cause physical dependence, which is associated with the consequences of stopping the drug in the baby. Therefore, it is forbidden to use this medicine during pregnancy, unless it is done with the opinion of a specialist.
Breastfeeding: This drug is secreted in breast milk and may cause drowsiness, problems in feeding and weight loss in infants. Therefore, it is not recommended to use the drug during breastfeeding.

Regarding the correct way to take the medicine, pay attention to these points:

1- Use this medicine only according to the doctor’s prescription. Avoid taking more amounts, number and frequency than prescribed by the doctor. Taking large amounts of this drug may cause drug dependence.
2- If you feel that the medicine is not effective within a few weeks of taking it, avoid increasing the amount of medicine and consult your doctor.
3- In order to control convulsive attacks, the drug must be taken every day at specific intervals according to the doctor’s order. This issue is necessary to keep the amount of medicine in the blood constant. Also, don’t forget to take any of the turns.
4- If you forget a dose of medicine, take it immediately as soon as you remember within an hour of the missed dose. But if it is almost time for the next dose, take only that dose and avoid doubling the dose.

Clobium drug interactions:

Before taking this medicine, inform your doctor if you are using the following medicines.
Other addictive drugs, especially drugs that weaken the central nervous system with an addictive effect – long-term and simultaneous use of these drugs may increase the risk of drug dependence.
Alcohol and other central nervous system depressant drugs – Concomitant use may increase the central nervous system depressant effects of these drugs. It is not recommended to drink alcoholic beverages during treatment with this medicine. In case of simultaneous use of clobazam and a narcotic pain reliever, the amount of narcotic pain reliever should be reduced by at least one third.
Carbamazepine – simultaneous use of drugs may increase the rate of metabolism, decrease serum concentrations and elimination half-life of clobazam. The amount of carbamazepine in the blood may increase, so it is recommended to monitor the amount of carbamazepine in the blood.
Clozapine – Collapse with weakening or sudden cessation of the respiratory system has been reported in a number of patients with concomitant use of the drugs. In some cases, it is recommended to stop using clobazam at least one week before starting treatment with clozapine.
Itraconazole and ketoconazole – simultaneous use of drugs is prohibited.
Levodopa – simultaneous use of drugs may reduce the therapeutic effects of levodopa.
Zidovudine – in simultaneous use with clobazam, the excretion of zidovudine decreases.

Clobium precautions:

  1. In case of regular and long-term use of the drug, pay attention to the following points.
    In order to check the progress of the treatment and ensure that there are no unwanted side effects, visit your doctor regularly. Also, considering the use of drugs in convulsive attacks, this issue is important in the first few months of treatment – the need to continue taking the drug should be regularly monitored by the doctor.
  2. It may be necessary to carry a medical identification card or a bracelet that represents the use of medicine by you.
  3. This drug may cause psychological or physical dependence, especially if it is consumed in large amounts for a long time. Some symptoms of drug dependence are:
    Great desire or need to continue taking the drug
    The need to increase the dosage of the drug in order to achieve its effects
    Side effects of discontinuing drug use (such as irritability, anger, sleep problems, abdominal or stomach contractions, tremors and tremors) that occur after discontinuing drug use.
  4. If you feel psychologically or physically dependent on this drug, consult your doctor and do not stop taking the drug suddenly.
  5. If you take the medicine in large quantities or for a long time, do not stop taking the medicine without consulting your doctor. Your doctor may reduce the dose gradually before stopping the medication completely.
  6. This drug may add to the effects of alcohol and other drugs that weaken the central nervous system (drugs that cause a decrease in alertness or sleepiness). Drugs that weaken the central nervous system include antihistamines with drugs effective against hay fever, other allergies or colds; pain relievers, sedatives, sleeping pills; prescription pain relievers with narcotic barbiturates, anticonvulsants, muscle relaxants; Anesthetic drugs include dental anesthetics. This effect may last for several days after stopping the drug. Consult your doctor before taking any of these drugs.
  7. If you suspect drug overdose, request emergency medical care immediately. Excessive use of the drug and its simultaneous use with alcoholic beverages or other drugs that weaken the central nervous system may lead to anesthesia and possibly death.
  8. In case of any medical tests, inform your doctor about taking this medicine.
  9. Inform your doctor about any unusual and strange thoughts or behavior while taking the medicine.
  10. This drug may cause drowsiness, confusion, dizziness, loss of work skills, instability, and decreased alertness, especially in elderly people. Even if used at bedtime, this medicine may make you feel drowsy or less alert when you wake up. Therefore, during treatment, avoid driving and working with devices that require sufficient alertness.

Contraindications to clobium:

1- History of allergy to clobazam and any of the components of this medicine
2- Insanity
3- Acute narrow-angle glaucoma
4- Children less than 6 months old
5- Simultaneous use with ketoconazole and itraconazole

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