common name:


Céphalexine (French)





Sefaleksin (Turkish)

What is Cephalexin?

Cephalexin is a broad-spectrum antibiotic and can act on a variety of microbes.
It is commonly used to treat urinary tract infections, skin infections, chest infections, throat, ear and tooth infections.
One of the benefits of this drug is that it can be prescribed for the treatment of adults and children. It can also be used to treat infections during pregnancy.
This drug helps to cure the infection and prevent its progression by killing the germs that cause the infection.
Some people who are allergic to penicillins may also be allergic to this medicine. Therefore, before starting treatment if you are allergic to any antibiotic, tell your doctor its name.

Indications Cephalexin:

It is used to treat infections caused by drug-sensitive gram-positive and gram-negative bacteria, including bone and joint infections, bacterial pneumonia, skin and soft tissue infections, tonsillitis, and urinary tract infections.

Mechanism of action of Cephalexin:

Like other antibiotics in this class, it prevents the formation of a cell wall in bacteria. The cell wall in the bacterium protects the cell against environmental factors, and if this wall is not fully formed, the bacterial cell will burst in an aqueous medium by absorbing water. Cephalexin in the final stage of peptidoglycan formation replaces the peptidoglycan constituents and causes the formation of an incomplete cell wall.

Before taking Cephalexin

Tell your doctor if you have a history of any drug allergies (especially allergies to antibiotics).
Although cephalexin has not been reported to be harmful to the fetus, tell your doctor if you are pregnant, pregnant or breast-feeding.
Since this drug can interfere with the function of other drugs in the body, it is necessary to provide a list of all your medications to your doctor or pharmacist before you start taking.
Tell your doctor if you have a history of kidney problems.

How to take Cephalexin

Take antibiotics exactly as your doctor advised and complete the course of treatment even if you feel better and your symptoms are gone because at this time the bacteria may not have been completely eradicated and this may lead to microbial resistance. increases.
Microbial resistance is one of the global problems that is increasing rapidly and if the overuse of inappropriate antibiotics in the world continues, we will face life-threatening problems. Improper use or length of treatment not only does not have the desired effects on the individual, but also leads to the lack of eradication of bacteria in the body and, in addition, bacteria that have been exposed to the drug but have not been killed. This leads to the development of a new and resistant generation of microbes that simply do not respond easily to existing antibiotics.
Because infections are commonly contagious, overuse of antibiotics can be problematic not only for the patient but also for others in the community.
Usually, this medicine is prescribed in the form of 4 capsules per day (1 every 6 hours). The appropriate dose for your infection will be determined by your doctor.
If the oral liquid form is prescribed for your child, the dosage will be calculated by the doctor according to their age and weight. Give the prescribed to the child.
Your doctor will determine the length of treatment with this medicine and you must take the medicine regularly until the end of the treatment period. Usually the treatment with this medicine is 5 to 7 days, but the doctor may have a shorter or longer period. Prescribe this amount for your infection.
If this medicine is prescribed to prevent urinary tract infection or to prevent recurrence of your urinary tract infection, you should usually take the medicine once a day, in which case you should take the medicine every evening and until your doctor recommends it. It seems to continue.
– This drug does not interfere with food and can be taken before or after food. However, if taken shortly before a meal, it works faster. If you miss a dose, take it immediately, but do not double the dose in a single dose.

Recommendations Cephalexin

Taking this drug may increase the renal side effects of other drugs (such as amioglycosides).
If you plan to have surgery or start medication for another condition, tell your therapist if you are taking this medication.
In some people, taking antibiotics causes red lesions with itching in the mouth or vagina. See your doctor if these symptoms occur.
Women, if you are taking birth control pills at the same time as the cephalexin treatment course, if you have any illness that is accompanied by diarrhea and vomiting that lasts more than 24 hours, it is necessary to use another method of prevention. Use pregnancy (such as a condom) with caution with birth control pills.
In case of any vaccination, inform your doctor about taking this medicine
Although treatment with this drug is generally short-term, in case of long-term use, periodic tests to check the liver and kidney status prescribed by a doctor are necessary.

Common side effects of Cephalexin

Mild diarrhea at the beginning of treatment is a common side effect of cephalexin that resolves on its own. If it occurs, drink plenty of fluids, but if the diarrhea persists for more than 24 hours and becomes more severe or contains blood, See your doctor.
Nausea, abdominal pain and indigestion may occur during treatment with this drug, to improve it, eating light and simple foods and taking the drug after a meal can help.

Rare but important side effects

If you have symptoms of drug allergies such as red and itchy skin lesions, shortness of breath, swelling of the face or lips, stop taking the medicine and see a doctor or medical center.
– This drug can have rare but important side effects that, although the probability of their occurrence is low, but it is very important to follow and pay attention to them. Therefore, if you have symptoms of cough with sore throat, dryness and inflammation of the eyes and red spots. Skin See your doctor or health care provider right away.


The prepared drug suspension can be stored in the refrigerator for a maximum of 10 to 14 days.

Pharmacokinetics of Cephalexin

95% of the drug is absorbed orally and its serum concentration reaches its peak after one hour. The half-life of the drug is approximately 0.5-1.9 hours, which may increase to 40 hours in case of renal failure. Eighty percent of the drug is excreted by the kidneys through tubular secretion.

Contraindications to Cephalexin

It should not be used if you have a history of hypersensitivity to cephalosporins, penicillins and their derivatives, or penicillamine or porphyria.

Side effects of Cephalexin

Central nervous system: agitation, dizziness, vertigo, fatigue, hallucinations, headache
Cutaneous: erythema multiforme, genital itching, skin rash, Stevens-Johnson syndrome, toxic epidermal necrosis, urticaria
Gastrointestinal: abdominal pain, diarrhea, indigestion, gastritis, nausea, pseudomembranous colitis, vomiting
Genitourinary: Genital candidiasis, vaginal discharge, vaginitis
Hematology and oncology: Increased eosinophil levels, hemolytic anemia, neutropenia, thrombocytopenia
Hepatic: cholestatic jaundice, hepatitis, elevated serum alanine aminotransferase, elevated serum aspartate aminotransferase
Hypersensitivity: Anaphylaxis, angioedema, hypersensitivity reaction
Neuromuscular and musculoskeletal: joint pain, arthritis, arthropathy
Renal: interstitial nephritis

Category X Interactions (Avoidance)

BCG (intravesical), cholera vaccine

Reducing the effects of drugs by Cephalexin:

Aminoglycosides, BCG (intravesical), BCG vaccine (immunogenic), cholera vaccine, lactobacillus and sterol, sodium picosulfate, tuberculosis vaccine

Reducing the effects of Cephalexin by drugs

Multivitamin / Mineral (Contains Vitamins A, D, E, K, Folate & Iron), Multivitamin / Mineral (Contains Vitamins A, E, & Iron Free), Sucrofric Oxyhydroxide, Zinc Salts

Increased effects of drugs by Cephalexin

Aminoglycosides, metformin, vitamin K antagonists

Increased effects of cephalexin by drugs:

Food interference:

Peak food consumption reduces and delays the serum concentration of antibiotics but does not affect the total amount of drug absorbed.
Serum levels of cephalexin may be reduced if taken with food.

Warnings Cephalexin

  1. Extreme caution should be exercised if you have a history of allergies to penicillins.
  2. This medicine may cause a false positive result on the Coombs or urine sugar test.
  3. This drug may cause pseudomembranous colitis.
  4. In patients with renal impairment, it is necessary to reduce the dose of the drug.

Cephalexin drug recommendations

1- The drug suspension will be stable for up to 14 days after preparation if stored in the refrigerator.
2- If you forget to take a medicine, you should take it as soon as you remember. However, if it is almost time for the next dose, the missed dose should be avoided and the next dose should not be doubled.
3- In case of severe diarrhea, you should consult a doctor before taking any anti-diarrhea drug.



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