Calendula

Indications

Oral and topical use, for inflammation of the mucous membrane of the mouth and pharynx
Topical use, for slow-healing wounds

Medicinal compounds

– Triterpene saponins
– Flavonoids (rutin, isoquercetin, hyperoside and astragalin)
– Hydroxycoumarins
– Carotenoids
– Water soluble polysaccharides
– Essential compounds (menthone, isomenthone, gammaterpenine, alphamorulene and caryophyllene)

Amount and method of consumption

Topical:

sufficient amount of oil should be applied and massaged 2-3 times a day on the target area.

Drug interactions

No interactions between the plant and drugs have been reported. Also, due to the common local use of the drug, the possibility of drug interaction is low.

Contraindications

Allergy to chicory family plants
Since in terms of traditional medicine, marigold is considered as a stimulant and some studies have reported its stimulating effects on the uterus, so it may cause abortion. Therefore, it should not be used during pregnancy.

side effects

Mild skin sensitivity

Mechanism of action

The flavonoids in marigold can prevent the release of histamine and the production of prostaglandins. Also, this group of compounds have other effects such as stabilizing the lysosome membrane and affecting capillary permeability and resistance. The saponins of this plant can prevent the release of histamine, bradykinin and some proteolytic enzymes. As a result, the secretion of plasma and the migration of white blood cells into the damaged tissue are hindered.

There are also reports that these substances stop the growth of some bacteria and fungi. Terpene alkaloids, lactones and flavones in the essential oil of marigolds have shown antimicrobial effects.
Marigold carotenoids, especially beta-carotene, are precursors of vitamin A and contribute to the anti-inflammatory and healing effects of flavonoids and saponosides. These compounds, together with the tannins in the plant, have been reported to be effective in preventing and improving the redness and pain caused by sunburn caused by ultraviolet rays.
The effects of stimulating and strengthening the immune system have been reported from the polysaccharide part isolated from the plant.

 

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