Common name:
Azithral
아지스랄(Korean)
Азитра(Tajik)
അസിത്രാൽ(Malayalam)
Азитрал(Russian)
Азітрал(Ukrainian)
What is Azithral?
Azithromycin is used to treat some acute bacterial infections such as lung, ear, skin infections, and in some cases vaginal and genital infections. It can be used in both adults and children.
This drug belongs to the class of macrolide antibiotics that prevent their survival and growth by causing a number of disorders in bacteria.
Azithromycin is a widely used antibiotic that comes in various forms of capsules and syrups.
The Food and Drug Administration (FDA) first approved azithromycin in 1991. Like all antibiotics, azithromycin can only fight certain bacteria. That’s why it is important to talk to your doctor before taking the medicine. Azithromycin is not effective against viral infections or as a sedative
Indications for azithromycin:
Azithromycin is used to treat respiratory tract infections, otitis media, skin and soft tissue infections, genital infections without chlamydial consequences, and non-gonococcal inflammation of the urethra.
Before taking Azithral
If you are pregnant or breastfeeding, have a history of liver or kidney problems, an abnormal heartbeat, or a history of drug allergies, be sure to tell your doctor before taking this medicine.
Because this medicine can interfere with the way other medicines work in the body, it is important to give your doctor or pharmacist a list of all your medicines before you start taking them.
How to take Azithral?
Take antibiotics exactly as your doctor advised and complete the course of treatment even if you feel better and your symptoms are gone because at this time the bacteria may not have been completely eradicated and this may increase the risk of microbial resistance. Increasing.
Microbial resistance is one of the global problems that is increasing rapidly and if the overuse of inappropriate antibiotics in the world continues, we will face life-threatening problems. Improper use or length of treatment not only does not have the desired effects on the individual, but also leads to the lack of eradication of bacteria in the body and, in addition, bacteria that have been exposed to the drug but have not been killed. This leads to the development of a new and resistant generation of microbes that simply do not respond easily to existing antibiotics.
Because infections are commonly contagious, overuse of antibiotics can be problematic not only for the patient but also for others in the community.
– Oral consumption of this drug may be in a single dose or in a period of 5 to 3 days, so be sure to ask your doctor or pharmacist about the amount and dose.
In children, the form of azithromycin suspension is usually prescribed and the amount to be taken at each time is determined by the doctor according to the weight and condition of the child. Due to the bitter taste of this drug, you can then give some juice to your child.
Azithromycin capsule form is best taken on an empty stomach (one hour before or two hours after a meal), but in case of stomach pain, it can be taken with food. But the tablet form and suspension of the drug do not interfere with food and can be taken before or after food.
Avoid taking antacid syrups for at least two hours with this medicine.
In case of any vaccination, inform your doctor about the use of this drug.
Azithral drug recommendations
According to the different forms of azithromycin, the recommendations of this drug are expressed according to the form of the drug:
Azithromycin 500 tablets, Azithromycin 250 tablets, Azithromycin 500 capsules and Azithromycin 250 capsules
– You can take the medicine with food.
Avoid driving and other activities that require full concentration and alertness for up to 2 hours after taking the drug.
Avoid taking antacid syrups containing aluminum and magnesium for at least 2 hours.
Tell your doctor if you are taking any heart medications.
Prolonged watery diarrhea with heartburn and up to a few weeks after treatment may be a rare side effect of this drug. Avoid self-medication.
If you notice signs of severe inflammation of the skin of the mouth or eyes, stop taking the medicine and see a doctor immediately.
Vial Azithral
This drug is hospitalized, so its maintenance and injection must be done in a medical center and under the supervision of a doctor.
Do not inject the medicine if the solution for injection has become cloudy or discolored.
Use a new syringe and needle for each injection.
Avoid driving and other activities that require full concentration and alertness for up to 2 hours after taking the drug.
Tell your doctor if you are taking any heart medications.
Prolonged watery diarrhea with heartburn and up to a few weeks after treatment may be a rare side effect of this drug. Avoid self-medication.
If you notice signs of severe inflammation of the skin of the mouth or eyes, stop taking the medicine and see a doctor immediately.
Azithral eye drops
Do not wear contact lenses until your symptoms improve and your doctor approves.
In case of any pain and hypersensitivity in the eye, see a doctor.
If you are prescribed several drops at the same time, ask your pharmacist how to use the drops and leave at least ten minutes between the two drops.
-After using the drops, you may experience a slight blurring of vision, so be more careful until the drug is effective in driving and tasks that require more care.
After dropping the drop in the inner cavity of the eye, close the eyes for one to two minutes and press the tear duct (both sides of the nose) with a little finger.
Side effects of َAzithral
Digestive: diarrhea, nausea, vomiting
Cardiovascular: chest pain, facial edema, palpitations
Skin: Increased sweating, eczema, fungal dermatitis, pruritus, skin sensitivity to light, skin rash, urticaria, vesiculobulosis dermatitis
Endocrinology and metabolism: decrease in serum glucose, increase in gamma glutamyl transferase, increase in lactate dehydrogenase, increase in serum glucose, increase in serum potassium
Gastrointestinal: Abdominal pain, anorexia, constipation, taste disturbance, indigestion, enteritis, bloating, gastritis, melena (dark bloody stools), oral candidiasis, oral inflammation
Genitourinary: Genital candidiasis, vaginitis
Hematology and oncology: anemia, increased eosinophil levels, increased neutrophils, leukopenia, lymphocytopenia, lymphocytosis, elevated platelet counts, monocytosis
Hepatic: cholestatic jaundice, increase in serum alanine aminotransferase, increase in serum aspartate aminotransferase, increase in serum bilirubin, jaundice
Hypersensitivity: Angioedema, hypersensitivity reaction
Infectious: A fungal infection
Topical: local inflammation, injection site pain
Nervous system: agitation, dizziness, drowsiness, fatigue, headache, insomnia, boredom, anger, pain, dizziness
Neuromuscular and musculoskeletal: Muscle hyperkinesia, increased creatine phosphokinase in blood samples
Renal: increased BUN, increased serum creatinine, nephritis
Respiratory: bronchospasm, cough, dehydration
Miscellaneous: Fever
Common side effects of Azithral
Mild diarrhea may occur as a result of taking this drug, which resolves over time, but if the diarrhea becomes severe and continues, see your doctor.
Feeling dizzy and tired, stomach ache and nausea are also common side effects of this drug, which is accompanied by a diet containing light and simple meals and containing suitable fiber, and by limiting fatty and spicy foods and consuming as much water at night. Reduce these symptoms during the day.
In case of headache, drink enough fluids and ask your pharmacist or doctor about the appropriate analgesic.
Rare complications
Endocrinology and metabolism: increase in serum bicarbonate, increase in serum phosphate, decrease in serum potassium, decrease in serum sodium
Hematology and oncology: Increased basophil levels, neutropenia
Hepatic: Increased serum alkaline phosphatase levels
Storage conditions of Azithromycin
Store the prepared drug suspension in the refrigerator for a maximum of 10 to 14 days.
– This drug can have rare but important side effects that, although the probability of their occurrence is low, but it is very important to follow and pay attention to them. Therefore, if you have symptoms of cough with sore throat, dryness and inflammation of the eyes and spots Red skin See your doctor or health care provider right away.
Azithral for sore throat
Diagnosis of the type of throat infection is made by a doctor for the use of appropriate antibiotics. If sore throat is viral, azithromycin tablets have no effect on sore throat, and if it is caused by streptococcus bacteria, azithromycin may be a good option. Of course, there were other antibiotics such as injectable penicillin, amoxicillin, coamoxyclav ….. However, the diagnosis of a viral infection from a bacterial infection is made by a physician because of the apparent similarity between the two.
Azithral 500
At first, the pharmaceutical companies produced only azithromycin 250 mg, but with the indiscriminate use of this drug, the effectiveness of azithromycin 250 gradually decreased and the pharmaceutical companies produced azithromycin 500 mg. Unfortunately, the bacteria are rapidly resisting azithromycin. There are 500 and this is the result of overuse of antibiotics. Azithromycin 500 is currently the highest dose available, and its daily dose is one per day.
Pharmacokinetics of Azithral
The bioavailability of this drug orally is about 40%. Absorption of the drug with food is reduced in the form of capsules (not tablets). The peak serum concentration of the drug is reached up to 2 hours later. The drug is widely distributed in tissues. So that its concentration in tissues will be more than plasma. This drug is metabolized in small amounts in the liver and the rest is excreted unchanged mainly through bile.
Contraindications to the use of Azithral
This medicine should not be used if you have liver failure.
Category X Interactions (Avoidance):
BCG (intravesical), Bilastin, cholera vaccine, doxorubicin (common), foxinidazole, misolastin, pazopanib, pimozide, strong CYP3A4 QT inhibitors (moderate risk), topotecan, vincristine (lip)
Interference with food
The amount and rate of gastrointestinal absorption may vary depending on the formulation. Absorption of azithromycin suspension (not tablets) is significantly increased (46%) when taken with food.
Solution: Quick release pills and suspension can be taken regardless of food. Slow-release suspension should be taken on an empty stomach (1 hour before or 2 hours after a meal).
Precautions Azithromycin
If the patient has liver or kidney disease, ventricular and porphyria should be used with extreme caution.
Azithromycin drug recommendations
It is better to take this medicine (especially its capsule) on an empty stomach, but in case of gastrointestinal irritation, the medicine can also be taken with food.
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