What is Apirax?

Apirax contains the active ingredient apixaban and belongs to the group of anticoagulants. This drug inhibits the process of blood clot formation by inhibiting coagulation factors. It is also able to dissolve and gradually eliminate clots formed in the arteries. Controlling clot formation or elimination of clots prevents pulmonary embolism and stroke caused by the movement of excised clots from deep arteries to the lungs and from the heart to the brain and other organs.


  • Reducing the risk of stroke and systemic embolism in non-valvular atrial fibrillation (NVAF)
  • Treatment of deep vein thrombosis (DVT)
  • Treatment of pulmonary embolism (PE)
  • Reduce the risk of DVT or PE recurrence
  • Prevention of DVT, which may lead to PE in patients undergoing knee or hip replacement surgery

When is Apirax prescribed?

  • Reduced risk of stroke and blood clotting in people with atrial fibrillation (except for patients with artificial valves and patients with moderate to severe mitral valve stenosis)
  • Prevention of blood clots in deep arteries such as leg arteries and pulmonary embolism in people who have had hip or knee replacement surgery.
  • Treatment of blood clots in the deep veins of the leg (deep vein thrombosis) or lungs (pulmonary embolism).
  • Reduce the risk of recurrence of deep vein thrombosis and pulmonary embolism

How to take Apirax?

  • This medicine can be taken with or without food and on an empty stomach
  • Take the medicine with a full glass of water
  • Consult your doctor to change the dose or stop taking Apirax.

How long does Apirax treatment last?

The duration of treatment with this drug varies depending on the type of disease and the effectiveness and the process of recovery and is determined by the treating physician. In some diseases, such as atrial fibrillation, continuous and long-term use of the drug is required, but in some cases, such as prevention of post-operative thrombosis of the knee or pelvic joint, if no clot develops, the duration of treatment is less than 2 months.

What are the contraindications to Apirax?

If you have abnormal and active bleeding

What are the common side effects of Apirax?

All drugs, along with their therapeutic effects, can cause side effects in some people, but this does not mean that they occur in all users. Side effects of Apirax in some consumers can occur as follows:

Allergic reactions, swelling of the face or tongue, shortness of breath in severe allergies, itchy skin, dizziness or weakness.
Bleeding: The main side effect of anticoagulants is bleeding.
Due to the properties and function of these drugs, their use may be associated with an increased risk of hidden or overt bleeding of any tissue or organ in the body, which can lead to anemia. Symptoms and severity of bleeding and anemia will vary depending on the location, extent and duration of the bleeding. The risk of bleeding is higher in certain patients, such as patients with uncontrolled and high arterial blood pressure. Complications of occult bleeding can include weakness, paleness, dizziness, headache, shortness of breath, and shock.

This complication may be in the form of bleeding from the oral mucosa, nosebleeds, coughing up blood or blood clots, menstrual bleeding or excessive vaginal bleeding, discoloration of the urine, discoloration of the stool, or active gastrointestinal bleeding and bleeding, any bleeding Prolonged and unexpected wounds.

Consult your doctor or pharmacist if you experience any side effects that may or may not go away.

What to do if you miss a dose?

If you remember the missed dose 6 hours before the next dose, take the medicine and take the next dose at the same time.
If you remember the missed dose less than 6 hours before the next dose, stop taking it and take the next dose as usual and at your own time.
Under no circumstances should you double the next dose because you forgot one dose.

Lesion or condition prone to severe bleeding

  • Active gastric ulcer
  • Recent injuries to the brain and spine
  • Active injury and bleeding in the eye
  • Suspicion of esophageal varices
  • Aneurysm (dilation of a vessel wall) in the brain or spinal cord
  • History of severe allergy to the active ingredient of the drug
  • If you have a metal prosthetic heart valve
  • In case of pregnancy and lactation
  • Concomitant use with other anticoagulants such as heparin, anaxaparin, warfarin, dabigatran, rivaroxaban (oxabin)
  • Liver failure or cirrhosis of the liver with coagulation problems
  • Hemorrhagic stroke

In what cases should Apirax be used with caution and should the physician be informed?

-Kidney and liver problems
-History of any disease and medical problem
-History of any abnormal bleeding
-Talk to your doctor before any surgery or medical or dental procedure. You may need to talk to both your current doctor and the doctor who prescribed Apirax about when to stop and restart         your medication. Decide. Arbitrary discontinuation of Apirax can increase the risk of stroke.

-Inform your doctor about all the medications you are taking (including all prescription and over-the-counter medications, vitamins and supplements, and herbal remedies).

What are the dietary restrictions while taking Apirax?

Unlike warfarin anticoagulant, Apirax does not interfere with foods, vegetables, and fruits, and you do not need to avoid diet-related medications while taking this medication, and you should only follow a diet related to the existing disease recommended by your doctor.

What drugs include drug interactions with Apirax (herbal, chemical)?

Apirax may affect the action of other drugs, and other drugs may affect the action of Apirax and increase the effect (increase the risk of bleeding) or reduce the effect (increase the risk of clot formation), so when seeing a doctor Be sure to bring a list of all medications and ask about herbal remedies and medicines.

Some medications that interact with Apirax include the following

Rifampin, phenytoin, phenobarbital, carbamazepine, sodium valproate, tacrolimus
Ketoconazole, Itraconazole, Vericonazole, Ritonavir, Indinavir, Nefazodone, Quinidine, Duftadyle, Sotalol

Some herbal remedies that should be used sparingly include:

Turmeric, Ginger, Garlic, Echinacea Purple, Ginkgo biloba, Ginseng, Green Tea, Chestnut, Spike
Consumption of herb tea is absolutely forbidden.

Is there a need for a blood test to check the effectiveness or level of blood concentration of the drug while taking Apirax?

No, unlike some anticoagulants such as warfarin, this drug does not need to be monitored effectively and tests such as PT and INR performed periodically. If special cases in the individual need to be examined, specialized tests will be requested by the treating physician.

What is the management of bleeding while taking the drug?

Mild bleeding:

In case of local bleeding such as bleeding from the nose and gums or small superficial incisions, it can be controlled by placing a cold compress on the site and pressing the bleeding site. There is no need to stop taking the drug and the next dose of apixaban tablets can be postponed for several hours. During menstruation, women do not need to stop taking the pill due to heavy bleeding, and they should go through this period by resting and consuming more fluids. If heavy bleeding interferes with daily activities and is not tolerable, consult your doctor to change or adjust medications.

Moderate to severe bleeding:

In moderate to severe bleeding, such as blood in the urine or stool, vomiting containing blood clots, or coughing up blood, you should stop taking the medicine and see your doctor or emergency room. In these cases, specialized tests are needed to determine the cause of the bleeding, serum injections, and, if necessary, blood products and blood clotting factors.

Life-threatening bleeding:

In case of very severe bleeding that is life threatening, such as severe and active bleeding of the gastrointestinal tract, bleeding of internal organs, accident and severe trauma to the limbs or large cuts or cut arteries, etc., you should call the emergency room or the nearest emergency room. See a hospital. Discontinue the drug Apixaban and place the person under close monitoring and supervision in the emergency department or intensive care unit and receive blood coagulation factors and blood products. If necessary, surgery will be performed to control the injured limbs.





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