Aminophylline is used to treat reversible airway obstruction and acute asthma as a respiratory stimulant in neonatal apnea.
Acute pulmonary edema, congestive heart failure, persistent fever, liver disease, hyperthyroidism, sepsis, and epileptic disorders should be used with extreme caution.
Drug Interactions Aminodi
Co-administration of cimetidine, ciprofloxacin, erythromycin, propranolol and thiabendazole with aminophylline may increase the concentration of its active metabolite. Co-administration of phenytoin and rifampicin with theophylline and smoking may reduce its concentration. Concomitant administration of beta-adrenergic receptor blockers may inhibit the bronchodilator effects. Concomitant use of ketamine may lower the threshold for epileptic seizures.
- In case of long-term administration, measurement of serum concentration of serum theophylline concentration and evaluation of the patient’s response to it is recommended to achieve the appropriate therapeutic concentration and minimize the risk of toxicity.
- Aminophylline should not be mixed in a syringe with other medicines.
- Intramuscular injection of the drug is very stimulating. If bolus injection is given, aminophylline should be injected very slowly into a vein (for at least 20 minutes).
- If aminophylline is added to dextrose injection solutions, a pale yellow color may be produced, which is not a problem.
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