Janus kinase inhibitor, immunosuppressant and anti-inflammatory oral drug
Tablets of 5 and 10 mg
Tofacitinib as citrate
The mechanism of action:
Alpamont is an immunosuppressive drug that reduces inflammatory responses in the immune system by inhibiting the Janus kinase enzyme.
Indications of Alpamont:
Alpamont is the first approved oral drug from the class of JAK inhibitors, which is used in the treatment of adults with moderate to severe types of “rheumatoid arthritis” and “ulcerative colitis”, “active psoriatic arthritis” and “active ankylosing spondylitis”. In addition, Alpamont is approved for the treatment of children with “active polyarticular juvenile idiopathic arthritis”, who are two years of age and older.
In all the mentioned indications, if the patient did not respond to the previous treatments (at least one TNF inhibitor) or was unable to tolerate the treatment, Alpamont is prescribed at the discretion of the attending physician.
Use in pregnancy and breastfeeding:
The safety of this drug during pregnancy is not known, and it should not be used during pregnancy. During the treatment and for at least four weeks after the end of the treatment period, safe methods of contraception should be used.
Alpamont excretion in breast milk is not known; Breastfeeding should not be done while taking this medicine. Breastfeeding is not recommended during treatment and at least 18 hours after the last dose
Regarding the correct way to use this medicine, pay attention to the following points:
Take Alpamont exactly as prescribed by your doctor. If you are not sure, consult your doctor or pharmacist.
Alpamont is an oral tablet that you can take without considering the time of meal.
Try to take your pill at the same time every day (one in the morning and one in the evening).
If you take more than the recommended amount, tell your doctor or pharmacist immediately.
If you forget to take a dose, use the forgotten medicine as soon as you remember and continue with the next dose as prescribed. If the time to remember the missed dose is close to the next dose, do not take the forgotten medicine and continue the next dose according to the prescription. Avoid taking the forgotten medicine and the next medicine at the same time.
Do not stop taking Alpamont without talking to your doctor.
The simultaneous use of some drugs interferes with Alpamont and can reduce the effectiveness or aggravate side effects. Therefore, if you are currently taking any type of medication or have recently taken any medication, consult your doctor or pharmacist.
The things mentioned in this guide sheet are not all drug interactions of Alpamont, consult your doctor for more information.
Among the important drug interactions of Alpamont, the following can be mentioned:
– Antifungal drugs such as fluconazole and vecoconazole
– Medicines that affect the immune system such as tacrolimus (dermal), cyclosporine, mercaptopurine and azathioprine
– Other biological drugs used in the treatment of rheumatoid arthritis such as adalimumab, etanercept, infleximab and rituximab
Antibiotics such as rifampin, which are used to treat bacterial infections
Talk to your doctor or pharmacist before taking alpamont:
• If you think you have an infection or have symptoms of an infection such as fever, sweating, chills, muscle aches, cough, shortness of breath, sputum or change in sputum, weight loss, warm or red or painful skin, or body sores, problems or pain When swallowing, diarrhea or stomach pain, burning or frequent urination, feeling very tired
• If you have any disease that increases the chance of infection (eg diabetes, HIV/AIDS, or a weakened immune system)
• If you have any type of infection, have started treatment for any infectious disease or if you have recurrent infections
• If you have a history of tuberculosis or have been in close contact with someone who has tuberculosis, your doctor will test you for tuberculosis before starting Alpamont and may repeat the test during treatment.
• In case of any type of chronic lung disease
• If you have liver problems
• If you have or have had hepatitis B or hepatitis C (viruses that affect the liver). Your doctor may recommend a hepatitis test before starting treatment with Alpamonto or while taking this medicine.
• If you are over 65 years of age, have a history of any type of cancer or currently have cancer, are a smoker or have a history of smoking
• If you are at high risk of skin cancer, your doctor may recommend that you have regular skin exams while taking alpamont.
• If you have diverticulitis (a type of inflammation of the large intestine) or a stomach or intestinal ulcer
• If you have kidney problems
• Tell your doctor if you plan to get a vaccine. Certain types of vaccines should not be used while taking Alpamont. Before starting Alpamont, you must have all the recommended vaccinations
• There have been reports of blood clots in the lungs or veins in patients treated with tofacitinib if they have heart problems, high blood pressure or high cholesterol, are smokers, or have a history of smoking. Your doctor will assess your risk of developing blood clots in the lungs or veins and decide if alpamont is right for you.
If you experience sudden shortness of breath or trouble breathing, chest pain or upper back pain, leg or arm swelling, leg pain or inflammation, or redness or discoloration of the leg or arm while taking alpamont, call your doctor right away. speak.
• If you are allergic to alpamont or any of the other ingredients of this medicine
• In case of severe infection such as bloodstream infection or active tuberculosis
• If you have been told that you have severe liver problems, including cirrhosis of the liver
• If you are pregnant or breastfeeding
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