Specifications of drugs Akinidic
Biperidine is prescribed to treat the symptoms of Parkinson’s disease and drug-induced extra-pyramidal symptoms (except for late movement disorders).
Mechanism of action Akinidic
This drug helps to exchange the activity of cholinergic and dopaminergic systems in the basal ganglia by partially blocking the receptors of the central cholinergic system. In addition, it has some local anesthetic and antihistamine effects. It may also have a small effect on the cardiovascular and respiratory systems
The drug is completely absorbed orally and metabolized in the liver and excreted by the kidneys. The effect of the drug begins 10-30 minutes after intramuscular administration
In the presence of untreated urinary retention, angle-closure glaucoma, gastrointestinal obstruction and should not be used in children under 3 years of age.
Dry mouth, indigestion, confusion, blurred vision, urinary retention, palpitations, hypersensitivity, nervousness, hallucinations, drowsiness, hypotension (injectable form) are some of the side effects of the drug.
Concomitant use of this drug with other drugs that have muscarinic effects can cause side effects such as dry mouth, urinary retention, constipation and meningitis in the elderly. These include tricyclic antidepressants and MAO inhibitors, phenothiazines, antihistamines, amantadine, and disopramide. Bepridine reduces the effects of sublingual nitrates by causing dry mouth. Parasympathomimetic drugs reduce the effect of bepridine with ketoconazole and also counteract the gastrointestinal effects of cisapride.
Use with caution in the presence of cardiovascular disease, liver or kidney failure, glaucoma, intestinal obstruction and urinary retention or in the elderly
Avoid abrupt discontinuation of treatment.
Medication can affect things like driving that require restraint.
Avoid concomitant use of the drug with alcohol or other CNS depressants.
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