Abitant pharmaceutical grade:
Anti nausea caused by chemotherapy
80 mg capsule
The mechanism of action:
NK1 receptor antagonist
Various chemotherapy regimens may cause nausea and vomiting. This drug is used to control nausea and vomiting caused by various chemotherapy regimens.
Use in pregnancy and breastfeeding Abitant:
Pregnancy: Adequate and well-controlled studies have not been conducted in pregnant women. Its use during pregnancy is allowed under the supervision of a physician.
Lactation: The secretion of this drug in human milk has not yet been determined. Due to the possibility of serious side effects in infants, its use during breastfeeding is not recommended.
Regarding the correct way to take the medicine, pay attention to these points:
1- Before starting the treatment with this medicine and when using it again, read its instruction sheet.
2- In case of nausea and vomiting, stop taking this medicine and contact your doctor.
3- The drug may be taken on an empty stomach or with food.
4- If you forget to take a dose of medicine, take it immediately as soon as you remember. But if it is almost time for the next dose, forget the missed dose and resume your normal schedule. Avoid doubling the amount of medicine.
Abitant drug interactions
Before taking this medicine, inform your doctor if you are using the following medicines:
Astemizole, cisapride, pimozide and terfenadine – simultaneous use of these drugs with Abitant is prohibited.
Benzodiazepines such as alprazolam, midazolam and triazolam – Abitant may increase the amount of these drugs in the blood.
Carbamazepine – Carbamazepine may reduce the effectiveness of opiate by inducing its metabolism.
Clarithromycin, itraconazole, nefazodone, nelfinavir, ritonavir and troleandomycin – due to the possibility of increasing
The amount of aperpitant in the blood, their simultaneous use should be done with caution.
Dexamethasone and methylprednisolone – if taken orally at the same time as aprepitant, the amount
Consumption may be reduced by 50%. In case of intravenous injection, the amount of methylprednisolone should be reduced by about 25%.
Diltiazem – the amount of diltiazem and aprepitant in the blood may increase, so caution is recommended
Docetaxel, etoposide, ifosfamide, imatinib, irinotecan, paclitaxel, vinblastine, vincristine, vinorelbine
and other chemotherapy drugs – careful monitoring and caution are recommended.
Ketoconazole – simultaneous use increases the amount of aperpitant in the blood. Caution is essential.
Oral contraceptives – The effectiveness of oral contraceptives is possible
Decrease. Other alternative methods are recommended.
Paroxetine – the amount of paroxetine and aprepitant in the blood may decrease and weaken the effectiveness
Both are drugs.
Phenytoin – Both drugs may reduce the effectiveness of each other.
Rifampin – the amount of aprepitant in the blood may decrease and cause its effectiveness to decrease.
Tolbutamide-Eprepitant may induce the metabolism of tolbutamide.
Warfarin – After taking Aperpitant, the patient should be monitored for two weeks.
Precautions of Abitant:
1- In order to check the progress of treatment and control unwanted side effects, visit your doctor at regular intervals.
2- When taking this medicine, oral contraceptives may not work properly. In this case, unwanted pregnancies may occur. Therefore, when taking this medicine, other methods should be used to prevent pregnancy.
3- If the symptoms do not improve or worsen, consult your doctor.
4- Do not take other medicines without consulting your doctor.
prohibited usage of Abitant:
1- History of allergy to aperpitant or any of the components of this medicine
2- simultaneous use with pimozide, terfenadine, astemizole and cisapride
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